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Decorin Recombinant Protein | Dcn recombinant protein
Recombinant Mouse Decorin
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NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded preproprotein is proteolytically processed to generate a mature protein product, which is secreted into the extracellular space to regulate collagen fibril assembly. Homozygous knockout mice for this gene exhibit enhanced tumorigenesis in a liver cancer model, and defects in collagen fibrils, leading to weakened skin and tendons. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
Uniprot Description
DCN: May affect the rate of fibrils formation. Defects in DCN are the cause of congenital stromal corneal dystrophy (CSCD). Corneal dystrophies are inherited, bilateral, primary alterations of the cornea that are not associated with prior inflammation or secondary to systemic disease. Most show autosomal dominant inheritance. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted; Secreted, signal peptide; Extracellular matrix; Motility/polarity/chemotaxis
Cellular Component: collagen type VI; cytoplasm; extracellular matrix; extracellular region; extracellular space; proteinaceous extracellular matrix
Molecular Function: collagen binding; extracellular matrix binding; glycosaminoglycan binding; protein kinase inhibitor activity; protein N-terminus binding
Biological Process: cytokine and chemokine mediated signaling pathway; negative regulation of angiogenesis; negative regulation of JAK-STAT cascade; negative regulation of protein kinase activity; peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan; positive regulation of autophagy; positive regulation of macroautophagy; positive regulation of mitochondrial depolarization; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of transcription from RNA polymerase II promoter
Research Articles on Dcn
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Product Notes
The Dcn dcn (Catalog #AAA961085) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 35-354aa; Partial. The amino acid sequence is listed below: GIIPYDPDNP LISMCPYRCQ CHLRVVQCSD LGLDKVPWDF PPDTTLLDLQ NNKITEIKEG AFKNLKDLHT LILVNNKISK ISPEAFKPLV KLERLYLSKN QLKELPEKMP RTLQELRVHE NEITKLRKSD FNGLNNVLVI ELGGNPLKNS GIENGAFQGL KSLSYIRISD TNITAIPQGL PTSLTEVHLD GNKITKVDAP SLKGLINLSK LGLSFNSITV MENGSLANVP HLRELHLDNN KLLRVPAGLA QHKYIQVVYL HNNNISAVGQ NDFCRAGHPS RKASYSAVSL YGNPVRYWEI FPNTFRCVYV RSAIQLGNYK. It is sometimes possible for the material contained within the vial of "Decorin, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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