Netrin receptor DCC (DCC) Recombinant Protein | DCC recombinant protein

Recombinant Human Netrin receptor DCC (DCC) , partial

• Gene Names: DCC; CRC18; CRCR1; MRMV1; HGPPS2; IGDCC1; NTN1R1
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Netrin receptor DCC (DCC); Recombinant Human Netrin receptor DCC (DCC); partial; DCC recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 1447

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for DCC recombinant protein

This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.

NCBI and Uniprot Product Information

• NCBI GI #: 110431348
• NCBI GeneID: 1630
• NCBI Accession #: NP_005206.2
• NCBI GenBank Nucleotide #: NM_005215.3
• UniProt Accession #: P43146
• Molecular Weight: 158,457 Da
• NCBI Official Full Name: netrin receptor DCC
• NCBI Official Synonym Full Names: DCC netrin 1 receptor
• NCBI Official Symbol: DCC
• NCBI Official Synonym Symbols: CRC18; CRCR1; MRMV1; HGPPS2; IGDCC1; NTN1R1
• NCBI Protein Information: netrin receptor DCC
• UniProt Protein Name: Netrin receptor DCC
• Protein Family: Netrin receptor
• UniProt Gene Name: DCC
• UniProt Synonym Gene Names: IGDCC1

NCBI Description

This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. [provided by RefSeq, Oct 2009]

Uniprot Description

Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.