Mouse dachshund homolog 1 (Drosophila) ELISA Kit | DACH1 elisa kit
Mouse Dachshund homolog 1, DACH1 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
DACH1: Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin- dependent kinase inhibitors, including the p27Kip1 promoter. Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain. Belongs to the DACH/dachshund family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription factor; Motility/polarity/chemotaxis; DNA-binding
Cellular Component: nucleoplasm; transcription factor complex; intracellular membrane-bound organelle; cytoplasm; nucleolus; nucleus
Molecular Function: protein binding; DNA binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; development of primary female sexual characteristics; cell proliferation; transcription, DNA-dependent; suckling behavior; regulation of transcription, DNA-dependent; negative regulation of fibroblast proliferation; multicellular organismal development; respiratory gaseous exchange; negative regulation of transcription from RNA polymerase II promoter; transcriptional preinitiation complex assembly; negative regulation of cell migration
Research Articles on DACH1
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Product Notes
The Mouse DACH1 dach1 (Catalog #AAA9327632) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9327632 ELISA Kit recognizes Mouse DACH1. It is sometimes possible for the material contained within the vial of "dachshund homolog 1 (Drosophila), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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