Rat disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) ELISA Kit | DAB2 elisa kit
Rat Disabled homolog 2, DAB2 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
p59 isoform inhibits growth in prostatic epithelial cells [RGD, Feb 2006]
Uniprot Description
DAB2: an adaptor protein that interacts with Grb2, myosin VI, SMAD2/3, DIP1/2, Dvl-3, the integrin betasubunit, and c-Src. Negatively regulates canonical Wnt signaling by stabilizing the beta-catenin degradation complex. A component of the CSF-1 signal transduction pathway. Phosphorylated DAB2 inhibits adhesion and integrin signaling. Two alternatively spliced isoforms are described.
Protein type: Tumor suppressor; Adaptor/scaffold
Cellular Component: focal adhesion; clathrin-coated vesicle; intracellular membrane-bound organelle; perinuclear region of cytoplasm; cytoplasm; apical plasma membrane; plasma membrane; nucleolus; clathrin coated vesicle membrane; coated pit; nucleus; clathrin coat of coated pit
Molecular Function: integrin binding; protein C-terminus binding; clathrin binding; phosphatidylinositol-4,5-bisphosphate binding; protein binding; SMAD binding; phosphoinositide binding
Biological Process: cellular morphogenesis during differentiation; pinocytosis; positive regulation of cell adhesion; apoptosis; positive regulation of transcription, DNA-dependent; positive regulation of endocytosis; excretion; activation of JNK activity; clathrin cage assembly; protein transport; positive regulation of aldosterone biosynthetic process; positive regulation of RNA elongation from RNA polymerase II promoter; negative regulation of protein binding; positive regulation of receptor recycling; negative regulation of epithelial cell proliferation; integrin-mediated signaling pathway; receptor-mediated endocytosis; Wnt receptor signaling pathway; leading edge cell differentiation; in utero embryonic development; positive regulation of transforming growth factor beta receptor signaling pathway; endocytosis; response to steroid hormone stimulus; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; myeloid cell differentiation; negative regulation of cell growth; positive regulation of protein amino acid phosphorylation; negative regulation of transcription, DNA-dependent; endoderm development; positive regulation of cell migration; negative regulation of apoptosis
Research Articles on DAB2
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Product Notes
The Rat DAB2 dab2 (Catalog #AAA9333156) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9333156 ELISA Kit recognizes Rat DAB2. It is sometimes possible for the material contained within the vial of "disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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