Human Disabled homolog 2 ELISA Kit | DAB2 elisa kit

Human Disabled homolog 2 ELISA Kit

Cat. Num. AAA9428132

• Gene Names: DAB2; DOC2; DOC-2
• Reactivity: Human
• Synonyms: Disabled homolog 2; Human Disabled homolog 2 ELISA Kit; DOC-2; Differentially-expressed protein 2; DAB2; DOC2; DAB2 elisa kit

• Reactivity: Human

• Samples: Serum, plasma, tissue homogenates and other biological fluids.
• Detection Range: 0.156-10 ng/mL
• Sensitivity: Less than 0.078ng/mL
• Assay Time: 3-5h
• Sample Volume: 100T
• Detection Wavelength: 450 nm
• Preparation and Storage: Store at 4 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 349585060
• NCBI GeneID: 1601
• NCBI Accession #: NP_001231800.1
• NCBI GenBank Nucleotide #: NM_001244871.1
• UniProt Accession #: P98082; Q13598; Q9BTY0; Q9UK04; A6NES5
• Molecular Weight: 80,228 Da
• NCBI Official Full Name: disabled homolog 2 isoform 2
• NCBI Official Synonym Full Names: DAB2, clathrin adaptor protein
• NCBI Official Symbol: DAB2
• NCBI Official Synonym Symbols: DOC2; DOC-2
• NCBI Protein Information: disabled homolog 2
• UniProt Protein Name: Disabled homolog 2
• Protein Family: Disabled
• UniProt Gene Name: DAB2
• UniProt Synonym Gene Names: DOC2; DOC-2

NCBI Description

This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Uniprot Description

DAB2: an adaptor protein that interacts with Grb2, myosin VI, SMAD2/3, DIP1/2, Dvl-3, the integrin betasubunit, and c-Src. Negatively regulates canonical Wnt signaling by stabilizing the beta-catenin degradation complex. A component of the CSF-1 signal transduction pathway. Phosphorylated DAB2 inhibits adhesion and integrin signaling. Two alternatively spliced isoforms are described.

Protein type: Adaptor/scaffold; Tumor suppressor

Chromosomal Location of Human Ortholog: 5p13.1

Cellular Component: clathrin-coated vesicle; coated pit; cytosol; fibrillar center; focal adhesion; intracellular membrane-bound organelle; lysosomal membrane; nucleolus; plasma membrane

Molecular Function: protein binding; protein C-terminus binding; SMAD binding

Biological Process: cell proliferation; integrin-mediated signaling pathway; leading edge cell differentiation; negative regulation of apoptosis; negative regulation of protein binding; negative regulation of transcription, DNA-dependent; positive regulation of cell migration; positive regulation of endocytosis; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein amino acid phosphorylation; positive regulation of transcription, DNA-dependent; positive regulation of transforming growth factor beta receptor signaling pathway