Rat 25-hydroxyvitamin D-1 alpha hydroxylase ELISA Kit | CYP27B1 elisa kit
Mouse 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial (CYP27B1) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the inner mitochondrial membrane where it hydroxylates 25-hydroxyvitamin D3 at the 1alpha position. This reaction synthesizes 1alpha,25-dihydroxyvitamin D3, the active form of vitamin D3, which binds to the vitamin D receptor and regulates calcium metabolism. Thus this enzyme regulates the level of biologically active vitamin D and plays an important role in calcium homeostasis. Mutations in this gene can result in vitamin D-dependent rickets type I. [provided by RefSeq, Jul 2008]
Uniprot Description
CYP27B1: Catalyzes the conversion of 25-hydroxyvitamin D3 (25(OH)D) to 1-alpha,25-dihydroxyvitamin D3 (1,25(OH)2D) plays an important role in normal bone growth, calcium metabolism, and tissue differentiation. Defects in CYP27B1 are the cause of rickets vitamin D- dependent type 1A (VDDR1A); also known as pseudovitamin D deficiency rickets (PDDR). A disorder caused by a selective deficiency of the active form of vitamin D (1,25- dihydroxyvitamin D3) and resulting in defective bone mineralization and clinical features of rickets. Belongs to the cytochrome P450 family.
Protein type: Mitochondrial; Lipid Metabolism - steroid biosynthesis; Oxidoreductase; EC 1.14.13.13; Cell cycle regulation
Chromosomal Location of Human Ortholog: 12q14.1
Cellular Component: cytoplasm; mitochondrial outer membrane; mitochondrion
Molecular Function: calcidiol 1-monooxygenase activity; heme binding; iron ion binding
Biological Process: bone mineralization; calcium ion homeostasis; calcium ion transport; decidualization; fat-soluble vitamin metabolic process; negative regulation of cell growth; negative regulation of cell proliferation; positive regulation of keratinocyte differentiation; regulation of bone mineralization; response to estrogen stimulus; response to lipopolysaccharide; response to vitamin D; vitamin D catabolic process; vitamin D metabolic process; vitamin metabolic process; xenobiotic metabolic process
Disease: Vitamin D Hydroxylation-deficient Rickets, Type 1a
Research Articles on CYP27B1
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Product Notes
The Rat CYP27B1 cyp27b1 (Catalog #AAA2606762) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2606762 ELISA Kit recognizes Rat CYP27B1. It is sometimes possible for the material contained within the vial of "25-hydroxyvitamin D-1 alpha hydroxylase, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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