CXCL14 recombinant protein

CXCL14 Protein, Human, Recombinant, Biotinylated

Cat. Num. AAA8120543

• Gene Names: CXCL14; KEC; KS1; BMAC; BRAK; NJAC; MIP2G; MIP-2g; SCYB14
• Purity: >95% as determined by SDS-PAGE
• Synonyms: CXCL14; CXCL14 Protein; Human; Recombinant; Biotinylated; Human CXCL14/BRAK Protein; BMAC Protein; BRAK Protein; KEC Protein; KS1 Protein; MIP-2g Protein; MIP2G Protein; NJAC Protein; SCYB14 Protein; chemokine (C-X-C motif) ligand 14; CXCL14 recombinant protein

• Host: E Coli
• Purity/Purification: >95% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Ser35-Glu111

• Species: Human
• Predicted N Terminal: Met
• Tag: Native
• Protein Construction: A DNA sequence encoding human CXCL14 (O95715)(Ser35-Glu111) was expressed with a N-terminal Met. The purified protein was biotinylated in vitro.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Related Product Information for CXCL14 recombinant protein

Background: CXCL14 is a CXC chemokine family that exhibits antimicrobial activity and contains an amphipathic cationic alpha-helical region in the C-terminus, a characteristic structure of antimicrobial peptides (AMPs). CXCL14 is involved in cell recruitment, migration, activation, and homing in liver diseases and have been shown to be upregulated during acute liver injury in animal models. The CXC chemokine ligand 14 (CXCL14) had been show highly expressed in tumor-associated stromal cells, promoting tumor cell growth, and invasion. The stimulation of dysregulated CXCL14 expression by P. gingivalis may help promote dysbiosis and the development of chronic periodontitis. The level of CXCL14 expression may be a valuable adjuvant parameter to predict the prognosis of patients with oral carcinoma and may be a potential therapeutic target.

NCBI and Uniprot Product Information

• NCBI GI #: 20149565
• NCBI GeneID: 9547
• NCBI Accession #: NP_004878.2
• NCBI GenBank Nucleotide #: NM_004887.4
• UniProt Accession #: O95715; Q6UW97; Q86U69; Q9BTR1; Q9NS21; B3KQU8
• Molecular Weight: 13,078 Da
• NCBI Official Full Name: C-X-C motif chemokine 14
• NCBI Official Synonym Full Names: chemokine (C-X-C motif) ligand 14
• NCBI Official Symbol: CXCL14
• NCBI Official Synonym Symbols: KEC; KS1; BMAC; BRAK; NJAC; MIP2G; MIP-2g; SCYB14
• NCBI Protein Information: C-X-C motif chemokine 14; bolekine; MIP-2 gamma; chemokine BRAK; breast and kidney; tumor-suppressing chemokine; small-inducible cytokine B14; CXC chemokine in breast and kidney; small inducible cytokine subfamily B (Cys-X-Cys), member 14 (BRAK)
• UniProt Protein Name: C-X-C motif chemokine 14
• Protein Family: C-X-C motif chemokine
• UniProt Gene Name: CXCL14
• UniProt Synonym Gene Names: MIP2G; NJAC; SCYB14
• UniProt Entry Name: CXL14_HUMAN

NCBI Description

This gene belongs to the cytokine gene family which encode secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC (Cys-X-Cys) subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes but not for lymphocytes, dendritic cells, neutrophils or macrophages. It has been implicated that this cytokine is involved in the homeostasis of monocyte-derived macrophages rather than in inflammation. [provided by RefSeq, Jul 2008]

Uniprot Description

CXCL14: Potent chemoattractant for neutrophils, and weaker for dendritic cells. Not chemotactic for T-cells, B-cells, monocytes, natural killer cells or granulocytes. Does not inhibit proliferation of myeloid progenitors in colony formation assays. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Secreted, signal peptide; Motility/polarity/chemotaxis; Chemokine; Secreted

Chromosomal Location of Human Ortholog: 5q31

Cellular Component: Golgi apparatus; extracellular space

Molecular Function: chemokine activity

Biological Process: cell-cell signaling; immune response; signal transduction; negative regulation of myoblast differentiation; chemotaxis; inner ear development