GRO-alpha (CXCL1) Recombinant Protein | CXCL1 recombinant protein
Rat GRO-alpha (CXCL1) Recombinant
Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug).
Recombinant rat CXCL1/GRO-a is a disulfide-linked homodimeric protein consisting of 73 amino acid residue subunits, and migrates as an approximately 8 kDa protein under non-reducing and reducing conditions in SDS-PAGE.
Upon reconstitution, this cytokine can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C for six months, with a carrier protein without detectable loss of activity.
Avoid repeated freeze/thaw cycles.
• hsv infection and hsv-immune complex both trigger production of neutrophil activating molecules (il-8,gro- and gm-csf) in ocular mucosal cells .Invest. Ophthalmol. Vis. Sci., Apr 2008; 49: 492.
• mice deficient in the cxcr2 ligand, cxcl1 (kc/gro-), exhibit increased susceptibility to dextran sodium sulfate (dss) -induced colitis .Innate Immunity, Apr 2008; 14: 117 - 124.
• gro is highly expressed in adenocarcinoma of the colon and down-regulates fibulin-1 .Clin. Cancer Res., Oct 2006; 12: 5951 - 5959.
• gro- regulation in airway smooth muscle by il-1 and tnf-: role of nf-b and map kinases .Am J Physiol Lung Cell Mol Physiol, Jul 2006; 291: L66 - L74.
NCBI and Uniprot Product Information
NCBI Description
acts as a neutrophil chemoattractant; may play a role in acute phase inflammatory response [RGD, Feb 2006]
Uniprot Description
CXCL2: Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta(5-73) shows a highly enhanced hematopoietic activity. Belongs to the intercrine alpha (chemokine CxC) family.
Protein type: Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide
Cellular Component: extracellular space
Molecular Function: growth factor activity; chemokine activity; CXCR chemokine receptor binding
Biological Process: neutrophil chemotaxis; response to glucocorticoid stimulus; response to amphetamine; positive regulation of potassium ion transport; response to lipopolysaccharide; positive regulation of leukocyte chemotaxis; response to estradiol stimulus; regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; response to heat; response to molecule of bacterial origin; positive regulation of superoxide release; response to gamma radiation; immune response; acute inflammatory response
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Product Notes
The CXCL1 cxcl1 (Catalog #AAA553279) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: QTEVIATLKN GREACLDPEA PMVQKIVQKM LKGVPK. It is sometimes possible for the material contained within the vial of "GRO-alpha (CXCL1), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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