CTSE recombinant protein

Recombinant Mouse CTSE Protein

Cat. Num. AAA8248883

• Gene Names: Ctse; CE; CatE; A430072O03Rik; C920004C08Rik
• Reactivity: Mouse
• Applications: ELISA, Western Blot, SDS-Page
• Purity: Greater than 95% as determined by reducing SDS-PAGE.
• Synonyms: CTSE; Recombinant Mouse CTSE Protein; Cathepsin E; CTSE recombinant protein

• Host: Human cells
• Reactivity: Mouse
• Purity/Purification: Greater than 95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 muM filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
• Sequence: SCNVYSSVNE PLINYLDMEY FGTISIGTPP QNFTVIFDTG SSNLWVPSVY CTSPACKAHP VFHPSQSDTY TEVGNHFSIQ YGTGSLTGII GADQVSVEGL TVDGQQFGES VKEPGQTFVN AEFDGILGLG YPSLAAGGVT PVFDNMMAQN LVALPMFSVY LSSDPQGGSG SELTFGGYDP SHFSGSLNWI PVTKQAYWQI ALDGIQVGDT VMFCSEGCQA IVDTGTSLIT GPPDKIKQLQ EAIGATPIDG EYAVDCATLD TMPNVTFLIN EVSYTLNPTD YILPDLVEGM QFCGSGFQGL DIPPPAGPLW ILGDVFIRQF YSVFDRGNNQ VGLAPAVPVD HHHHHH
• Sequence Length: 397

• Applicable Applications for CTSE recombinant protein: ELISA (EIA),Western Blot (WB), SDS-PAGE, Mass Spectrometry (MS)
• Endotoxin: Less than 0.1 ng/mug (1 IEU/mug) as determined by LAL test.
• Directions for Use: Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 mug/ml. Dissolve the lyophilized protein in 1X PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
• Preparation and Storage: Lyophilized protein should be stored at -20 degree C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 2-8 degree C for 2-7 days. Aliquots of reconstituted samples are stable at -20 degree C for 3 months.

Related Product Information for CTSE recombinant protein

Recombinant Mouse CTSE Protein is produced by our mammalian expression system and the target gene encoding Ser60-Pro397 is expressed with a 6His tag at the C-terminus.

NCBI and Uniprot Product Information

• NCBI GI #: 166235886
• NCBI GeneID: 13034
• NCBI Accession #: NP_031825.2
• NCBI GenBank Nucleotide #: NM_007799.3
• UniProt Accession #: P70269; O35647; Q3UKT5; Q4FK00
• Molecular Weight: 42,938 Da
• NCBI Official Full Name: cathepsin E preproprotein
• NCBI Official Synonym Full Names: cathepsin E
• NCBI Official Symbol: Ctse
• NCBI Official Synonym Symbols: CE; CatE; A430072O03Rik; C920004C08Rik
• NCBI Protein Information: cathepsin E
• UniProt Protein Name: Cathepsin E
• Protein Family: Cathepsin
• UniProt Gene Name: Ctse
• UniProt Entry Name: CATE_MOUSE

NCBI Description

This gene encodes a member of the peptidase A1 family of aspartate proteases and preproprotein that is proteolytically processed to generate a mature protein product. The encoded protein may be involved in antigen processing and the maturation of secretory proteins. Elevated expression of this gene has been observed in neurodegeneration. Homozygous knockout mice for this gene exhibit lysosomal storage disorder, impaired autophagy, mitochondrial abnormalities, dermatitis, and reduced weight gain in an obesity model. [provided by RefSeq, Aug 2015]

Uniprot Description

CTSE: May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain. Belongs to the peptidase A1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.23.34; Protease

Cellular Component: endosome

Molecular Function: aspartic-type endopeptidase activity; protein homodimerization activity

Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; protein autoprocessing; protein catabolic process