Human Pro-Cathepsin B ELISA Kit | CTSB elisa kit

Pro-Cathepsin B (Human) OmniKine ELISA Kit

Cat. Num. AAA9502068

• Gene Names: CTSB; APPS; CPSB
• Reactivity: Human
• Synonyms: Pro-Cathepsin B; Pro-Cathepsin B (Human) OmniKine ELISA Kit; Cathepsin B; APP secretase; APPS; Cathepsin B1; CPSB; CTSB elisa kit

• Reactivity: Human
• Specificity: The OmniKine Human Pro-Cathepsin B ELISA is capable of recognizing both recombinant and naturally produced Human Pro-Cathepsin B proteins. The antigens listed below were tested at 160 ng/ml and did not exhibit significant cross reactivity or interference.; Human: Cathepsin A, Cathepsin C, Cathepsin D, Cathepsin E, Cathepsin L, Cathepsin S, Cathepsin V, Cathepsin X/Z/P, Cystatin C, Cystatin D, Cystatin SA; Murine: Cathepsin B
• Form/Format: 12 x 8-Well Microstrips
• Sequence Length: 339

• Samples: Plasma, serum, lysate
• Assay Type: Sandwich ELISA
• Detection Range: 250-16000 pg/ml
• Sensitivity: 250-16000 pg/ml
• Detection Method: Colorimetric 450 nm
• Subtype: None
• Preparation and Storage: Store at 4 degree C for 6 months.

Testing Data

(The OmniKine Human Pro-Cathepsin B ELISA Kit allows for the detection and quantification of endogenous levels of natural and/or recombinant Human Pro-Cathepsin B proteins within the range of 250-16000 pg/ml.)

NCBI and Uniprot Product Information

• NCBI GI #: 4503139
• NCBI GeneID: 1508
• NCBI Accession #: NP_001899.1
• NCBI GenBank Nucleotide #: NM_001908.4
• UniProt Accession #: P07858; Q503A6; Q96D87; B3KQR5; B3KRR5
• Molecular Weight: 37,822 Da
• NCBI Official Full Name: cathepsin B isoform 1 preproprotein
• NCBI Official Synonym Full Names: cathepsin B
• NCBI Official Symbol: CTSB
• NCBI Official Synonym Symbols: APPS; CPSB
• NCBI Protein Information: cathepsin B
• UniProt Protein Name: Cathepsin B
• Protein Family: Cathepsin
• UniProt Gene Name: CTSB
• UniProt Synonym Gene Names: CPSB; APPS

NCBI Description

This gene encodes a member of the C1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cathepsin B light and heavy chains, which can dimerize to form the double chain form of the enzyme. This enzyme is a lysosomal cysteine protease with both endopeptidase and exopeptidase activity that may play a role in protein turnover. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer's disease, the most common cause of dementia. Overexpression of the encoded protein has been associated with esophageal adenocarcinoma and other tumors. Multiple pseudogenes of this gene have been identified. [provided by RefSeq, Nov 2015]

Uniprot Description

CTSB: Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis. Dimer of a heavy chain and a light chain cross-linked by a disulfide bond. Interacts with SRPX2. Belongs to the peptidase C1 family.

Protein type: Autophagy; EC 3.4.22.1; Motility/polarity/chemotaxis; Protease

Chromosomal Location of Human Ortholog: 8p23.1

Cellular Component: extracellular region; extracellular space; intracellular; intracellular membrane-bound organelle; lysosome; melanosome; mitochondrion; nucleolus; perinuclear region of cytoplasm

Molecular Function: collagen binding; cysteine-type endopeptidase activity; cysteine-type peptidase activity; peptidase activity; protein binding; proteoglycan binding; serine-type endopeptidase activity

Biological Process: collagen catabolic process; decidualization; entry of virus into host cell; epithelial cell differentiation; neutrophil degranulation; proteolysis; proteolysis involved in cellular protein catabolic process; regulation of apoptosis; regulation of catalytic activity; toll-like receptor signaling pathway