Typical Testing Data/Standard Curve (for reference only)
Mouse Cystathionine gamma-lyase ELISA Kit | Cth elisa kit
Mouse Cystathionine gamma-lyase ELISA Kit
Typical Testing Data/Standard Curve (for reference only)
Typical Testing Data/Standard Curve (for reference only)
NCBI and Uniprot Product Information
Uniprot Description
CTH: Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target proteins: sulfhydration consists of converting -SH groups into -SSH on specific cysteine residues of target proteins such as GAPDH, PTPN1 and NF-kappa-B subunit RELA, thereby regulating their function. Defects in CTH are the cause of cystathioninuria (CSTNU). It is an autosomal recessive phenotype characterized by abnormal accumulation of plasma cystathionine, leading to increased urinary excretion. Belongs to the trans-sulfuration enzymes family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Amino Acid Metabolism - glycine, serine and threonine; EC 4.4.1.1; Cell cycle regulation; Lyase; Other Amino Acids Metabolism - selenoamino acid; Energy Metabolism - nitrogen; Amino Acid Metabolism - cysteine and methionine
Cellular Component: cytoplasm; nucleus
Molecular Function: calmodulin binding; catalytic activity; cystathionine beta-lyase activity; cystathionine gamma-lyase activity; lyase activity; protein binding; pyridoxal phosphate binding
Biological Process: activation of NF-kappaB transcription factor; amino acid biosynthetic process; cysteine biosynthetic process; cysteine biosynthetic process via cystathionine; glutathione metabolic process; homocysteine metabolic process; negative regulation of apoptosis; negative regulation of cell growth; negative regulation of cell proliferation; positive regulation of I-kappaB kinase/NF-kappaB cascade; protein homotetramerization; protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine; transsulfuration
Research Articles on Cth
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Product Notes
The Mouse Cth cth (Catalog #AAA2883276) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2883276 ELISA Kit recognizes Mouse Cth. It is sometimes possible for the material contained within the vial of "Cystathionine gamma-lyase, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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