Human Cutaneous T-Cell Lymphocyte Associated Antigen ELISA Kit | CTAGE elisa kit

Human Cutaneous T-Cell Lymphocyte Associated Antigen ELISA Kit

Cat. Num. AAA34412

• Gene Names: CCR6; BN-1; DCR2; DRY6; CCR-6; CD196; CKRL3; GPR29; CKR-L3; CMKBR6; GPRCY4; STRL22; CC-CKR-6; C-C CKR-6
• Reactivity: Human
• Synonyms: Cutaneous T-Cell Lymphocyte Associated Antigen; Human Cutaneous T-Cell Lymphocyte Associated Antigen ELISA Kit; CTAGE elisa kit

• Reactivity: Human
• Sequence Length: 374

• Assay Type: Sandwich
• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 37188165
• NCBI GeneID: 1235
• NCBI Accession #: NP_113597.2
• NCBI GenBank Nucleotide #: NM_031409.3
• UniProt Accession #: P51684; P78553; Q92846; E1P5C6
• Molecular Weight: 42,494 Da
• NCBI Official Full Name: C-C chemokine receptor type 6
• NCBI Official Synonym Full Names: chemokine (C-C motif) receptor 6
• NCBI Official Symbol: CCR6
• NCBI Official Synonym Symbols: BN-1; DCR2; DRY6; CCR-6; CD196; CKRL3; GPR29; CKR-L3; CMKBR6; GPRCY4; STRL22; CC-CKR-6; C-C CKR-6
• NCBI Protein Information: C-C chemokine receptor type 6; LARC receptor; chemokine receptor-like 3; chemokine (C-C) receptor 6; G protein-coupled receptor 29; G-protein coupled receptor 29; seven-transmembrane receptor, lymphocyte, 22
• UniProt Protein Name: C-C chemokine receptor type 6
• UniProt Gene Name: CCR6
• UniProt Synonym Gene Names: CKRL3; CMKBR6; GPR29; STRL22; C-C CKR-6; CC-CKR-6; CCR-6; CKR-L3; GPRCY4
• UniProt Entry Name: CCR6_HUMAN

NCBI Description

This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. Alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

CCR6: Receptor for a C-C type chemokine. Binds to MIP-3- alpha/LARC and subsequently transduces a signal by increasing the intracellular calcium ions level. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, GPCR; Motility/polarity/chemotaxis; Membrane protein, integral; GPCR, family 1; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 6q27

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: C-C chemokine receptor activity; chemokine receptor activity; receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; innate immune response; cellular defense response; dendritic cell chemotaxis; immune response; signal transduction; chemotaxis; cell motility; humoral immune response