CSF3R / Granulocyte Colony-Stimulating Factor Receptor Recombinant Protein | CSF3R recombinant protein

Human CSF3R / Granulocyte Colony-Stimulating Factor Receptor Recombinant Protein

• Gene Names: CSF3R; SCN7; CD114; GCSFR
• Applications: ELISA, Western Blot
• Purity: >95% by SDS-PAGE
• Synonyms: CSF3R / Granulocyte Colony-Stimulating Factor Receptor; Human CSF3R / Granulocyte Colony-Stimulating Factor Receptor Recombinant Protein; Granulocyte colony-stimulating factor receptor; G-CSF receptor; CD114; GCSFR; CSF3R recombinant protein

• Host: E Coli
• Purity/Purification: >95% by SDS-PAGE
• Form/Format: Liquid; 50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10% Glycerol (PH8.0)
• Concentration: Reconstitution Dependent (varies by lot)
• Sequence Length: 783

• Applicable Applications for CSF3R recombinant protein: ELISA (EIA), Western Blot (WB), Antigen Protein (AP), Protein Array
• Species: Human
• Tag: His
• Subunit: Homodimer. The dimeric receptor binds two CSF3 molecules. Interacts with CEACAM1; down-regulates the CSF3R-STAT3 pathway through recruitment of PTPN6 that dephosphorylates CSF3R.
• Entry Function: Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface.
• Preparation and Storage: Store at -20 degree C. Avoid repeated freezing and thawing.

NCBI and Uniprot Product Information

• NCBI GI #: 27437045
• NCBI GeneID: 1441
• NCBI Accession #: NP_758519.1
• NCBI GenBank Nucleotide #: NP_758519.1
• UniProt Accession #: Q99062
• NCBI Official Full Name: granulocyte colony-stimulating factor receptor isoform d
• NCBI Official Synonym Full Names: colony stimulating factor 3 receptor
• NCBI Official Symbol: CSF3R
• NCBI Official Synonym Symbols: SCN7; CD114; GCSFR
• NCBI Protein Information: granulocyte colony-stimulating factor receptor
• UniProt Protein Name: Granulocyte colony-stimulating factor receptor
• Protein Family: Granulocyte colony-stimulating factor receptor
• UniProt Gene Name: CSF3R
• UniProt Synonym Gene Names: GCSFR; G-CSF receptor; G-CSF-R
• UniProt Entry Name: CSF3R_HUMAN

NCBI Description

The protein encoded by this gene is the receptor for colony stimulating factor 3, a cytokine that controls the production, differentiation, and function of granulocytes. The encoded protein, which is a member of the family of cytokine receptors, may also function in some cell surface adhesion or recognition processes. Alternatively spliced transcript variants have been described. Mutations in this gene are a cause of Kostmann syndrome, also known as severe congenital neutropenia. [provided by RefSeq, Aug 2010]

Uniprot Description

GCSFR: the receptor for colony stimulating factor 3, a cytokine that controls the production, differentiation, and function of granulocytes. The encoded protein, which is a member of the family of cytokine receptors, may also function in some cell surface adhesion or recognition processes. Four transcript variant isoforms have been described.

Protein type: Receptor, cytokine; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p35-p34.3

Cellular Component: integral to plasma membrane; extracellular region

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding; receptor activity

Biological Process: neutrophil chemotaxis; cytokine and chemokine mediated signaling pathway; defense response; signal transduction; cell adhesion

Disease: Neutrophilia, Hereditary