C-Reactive Protein Recombinant Protein | CRP recombinant protein

Recombinant Human C-Reactive Protein (CRP)

Cat. Num. AAA283669

• Gene Names: CRP; PTX1
• Applications: Western Blot, ELISA
• Purity: >97% as determined by SDS-PAGE; Inclusions renaturation and purification
• Synonyms: C-Reactive Protein; Recombinant Human C-Reactive Protein (CRP); CRP recombinant protein

• Host: E Coli
• Purity/Purification: >97% as determined by SDS-PAGE; Inclusions renaturation and purification
• Form/Format: Lyophilized Powder
• Sequence Length: 224

• Applicable Applications for CRP recombinant protein: Western Blot (WB), ELISA (EIA)
• Application Notes: Western blotting, ELISA, Albumin-bound fluorescence was used in serum of patients with chronic renal failure.
• Species of Origin: Human
• Endotoxin: < 1.0 EU per mug of the protein as determined by the LAL method
• Storage Buffer: Lyophilized from sterile PBS, pH 7.4
• Preparation and Storage: Store it under sterile conditions at -20 degree C to -80 degree C upon receiving. Recommend to aliquot the protein into smaller quantities for optimal storage.

Related Product Information for CRP recombinant protein

C-reactive protein (CRP) is synthesized by the liver in response to factors released by fat cells. It is a member of the pentraxin family of proteins. The levels of CRP rise in response to inflammation. Human C-reactive protein (CRP) is the classical acute phase reactant, the circulating concentration of which rises rapidly and extensively in a cytokine-mediated response to tissue injury, infection and inflammation. Serum CRP values are routinely measured, empirically, to detect and monitor many human diseases. However, CRP is likely to have important host defence, scavenging and metabolic functions through its capacity for calcium-dependent binding to exogenous and autologous molecules containing phosphocholine (PC) and then activating the classical complement pathway. CRP may also have pathogenic effects and the recent discovery of a prognostic association between increased CRP production and coronary atherothrombotic events is of particular interest.

NCBI and Uniprot Product Information

• NCBI GI #: 55770842
• NCBI GeneID: 1401
• NCBI Accession #: NP_000558.2
• NCBI GenBank Nucleotide #: NM_000567.2
• Molecular Weight: 24.7 kDa
• NCBI Official Full Name: C-reactive protein
• NCBI Official Synonym Full Names: C-reactive protein, pentraxin-related
• NCBI Official Symbol: CRP
• NCBI Official Synonym Symbols: PTX1
• NCBI Protein Information: C-reactive protein; pentraxin 1
• UniProt Protein Name: C-reactive protein
• Protein Family: Cryparin
• UniProt Gene Name: CRP
• UniProt Synonym Gene Names: PTX1
• UniProt Entry Name: CRP_HUMAN

NCBI Description

The protein encoded by this gene belongs to the pentaxin family. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli. [provided by RefSeq, Sep 2009]

Uniprot Description

CRP: Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. Belongs to the pentaxin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 1q23.2

Cellular Component: extracellular space; growth cone; extracellular region; filopodium

Molecular Function: choline binding; protein binding; protein homodimerization activity; low-density lipoprotein receptor binding; complement component C1q binding; low-density lipoprotein binding; virion binding; cholesterol binding; calcium ion binding

Biological Process: protein polymerization; defense response to Gram-positive bacterium; response to ethanol; wound healing; negative regulation of vasodilation; positive regulation of superoxide release; response to lead ion; acute-phase response; response to hypoxia; opsonization; inflammatory response; complement activation, classical pathway; aging