Thymic Stromal Lymphopoietin Recombinant Protein | TSLPR recombinant protein

Recombinant Human Thymic Stromal Lymphopoietin Receptor

Cat. Num. AAA145592

• Gene Names: CRLF2; CRL2; TSLPR; CRLF2Y
• Purity: Greater than 85.0% as determined by SDS-PAGE.
• Synonyms: Thymic Stromal Lymphopoietin; Recombinant Human Thymic Stromal Lymphopoietin Receptor; TSLPR Human; Thymic Stromal Lymphopoietin Receptor Human Recombinant; CRL2; CRLF2Y; Cytokine receptor-like factor 2; Cytokine receptor-like 2; IL-XR; ILXR; TSLPR recombinant protein

• Host: E Coli
• Purity/Purification: Greater than 85.0% as determined by SDS-PAGE.
• Form/Format: TSLPR protein solution (1mg/ml) contains 20mM Tris-HCl buffer, (pH 8.0), 0.4M UREA and 10% glycerol.; Sterile filtered colorless solution.
• Sequence: MGSSHHHHHH SSGLVPRGSH MGSQGGAAEG VQIQIIYFNL ETVQVTWNAS KYSRTNLTFH YRFNGDEAYD QCTNYLLQEG HTSGCLLDAE QRDDILYFSI RNGTHPVFTA SRWMVYYLKP SSPKHVRFSW HQDAVTVTCS DLSYGDLLYE VQYRSPFDTE WQSKQENTCN VTIEGLDAEK CYSFWVRVKA MEDVYGPDTY PSDWSEVTCW QRGEIRDACA ETPTPPKPKL SK
• Sequence Length: 259

• Preparation and Storage: Store at 4 degree C if entire vial will be used within 2-4 weeks.Store, frozen at -20 degree C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

Related Product Information for TSLPR recombinant protein

Description: TSLPR Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 232 amino acids (23-231 a.a.) and having a molecular mass of 26.6kDa.TSLPR is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Introduction: Thymic Stromal Lymphopoietin Receptor (TSLPR) is a member of the type I cytokine receptor family. TSLPR alongside the interleukin 7 receptor (IL7R) activate STAT3, STAT5, and JAK2 pathways, which is regulated processes such as cell proliferation and development of the hematopoietic system. Two transcript variants encoding dissimilar isoforms have been found for this gene. TSLPR is expressed in heart, skeletal muscle, kidney and adult and fetal liver.

Product Categories/Family for TSLPR recombinant protein

Cytokines and Growth Factors; Cytokines

NCBI and Uniprot Product Information

• NCBI GI #: 589269166
• NCBI GeneID: 64109
• NCBI Accession #: NP_001012288.2
• NCBI GenBank Nucleotide #: NM_001012288.2
• UniProt Accession #: Q9HC73; Q5G7M1; Q9H5R3; J3QKD1
• Molecular Weight: 29,360 Da
• NCBI Official Full Name: cytokine receptor-like factor 2 isoform 2
• NCBI Official Synonym Full Names: cytokine receptor-like factor 2
• NCBI Official Symbol: CRLF2
• NCBI Official Synonym Symbols: CRL2; TSLPR; CRLF2Y
• NCBI Protein Information: cytokine receptor-like factor 2; IL-XR; TSLP receptor; cytokine receptor CRL2 precusor; thymic stromal lymphopoietin protein receptor; thymic stromal-derived lymphopoietin receptor
• UniProt Protein Name: Cytokine receptor-like factor 2
• Protein Family: Thymic stromal lymphopoietin
• UniProt Gene Name: CRLF2
• UniProt Synonym Gene Names: CRL2; ILXR; TSLPR; TSLP receptor
• UniProt Entry Name: CRLF2_HUMAN

NCBI Description

This gene encodes a member of the type I cytokine receptor family. The encoded protein is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Rearrangement of this gene with immunoglobulin heavy chain gene (IGH) on chromosome 14, or with P2Y purinoceptor 8 gene (P2RY8) on the same X or Y chromosomes is associated with B-progenitor acute lymphoblastic leukemia (ALL) and Down syndrome ALL. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]

Uniprot Description

CRLF2: Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2. Implicated in the development of the hematopoietic system. Belongs to the type I cytokine receptor family. Type 5 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: Xp22.3; Yp11.3

Cellular Component: extracellular region; plasma membrane; integral to membrane