Corticotropin-releasing factor receptor 1 (CRHR1) Recombinant Protein | CRHR1 recombinant protein
Recombinant Human Corticotropin-releasing factor receptor 1 (CRHR1)
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a G-protein coupled receptor that binds neuropeptides of the corticotropin releasing hormone family that are major regulators of the hypothalamic-pituitary-adrenal pathway. The encoded protein is essential for the activation of signal transduction pathways that regulate diverse physiological processes including stress, reproduction, immune response and obesity. Alternative splicing results in multiple transcript variants. Readthrough transcription also exists between this gene and upstream GeneID:401884 (ADP-ribosylation factor 3 pseudogene), and the readthrough transcripts encode isoforms that share similarity with the products of this gene. [provided by RefSeq, Dec 2014]
Uniprot Description
CRF-R1: a G-protein coupled receptor that specifically binds corticotropin-releasing hormone, a potent mediator of endocrine, autonomic, behavioral, and immune responses to stress. Four splice-variant isoforms have been described.
Protein type: Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 2
Chromosomal Location of Human Ortholog: 17q21.31
Cellular Component: endosome; integral to membrane; integral to plasma membrane; intrinsic to plasma membrane; plasma membrane
Molecular Function: corticotrophin-releasing factor receptor activity; protein binding
Biological Process: adenylate cyclase activation; adrenocorticotropin hormone secretion; cell surface receptor linked signal transduction; female pregnancy; immune response; parturition
Research Articles on CRHR1
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Product Notes
The CRHR1 crhr1 (Catalog #AAA7013045) is a Recombinant Protein produced from Cell Free Expression and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 24-444aa; Full length protein. This is a recombinant transmembrane protein expressed in a cell-free expression system. Researchers should empirically determine the suitability of the CRHR1 crhr1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: SLQDQHCESL SLASNISGLQ CNASVDLIGT CWPRSPAGQL VVRPCPAFFY GVRYNTTNNG YRECLANGSW AARVNYSECQ EILNEEKKSK VHYHVAVIIN YLGHCISLVA LLVAFVLFLR LRPGCTHWGD QADGALEVGA PWSGAPFQVR RSIRCLRNII HWNLISAFIL RNATWFVVQL TMSPEVHQSN VGWCRLVTAA YNYFHVTNFF WMFGEGCYLH TAIVLTYSTD RLRKWMFICI GWGVPFPIIV AWAIGKLYYD NEKCWFGKRP GVYTDYIYQG PMILVLLINF IFLFNIVRIL MTKLRASTTS ETIQYRKAVK ATLVLLPLLG ITYMLFFVNP GEDEVSRVVF IYFNSFLESF QGFFVSVFYC FLNSEVRSAI RKRWHRWQDK HSIRARVARA MSIPTSPTRV SFHSIKQSTA V. It is sometimes possible for the material contained within the vial of "Corticotropin-releasing factor receptor 1 (CRHR1), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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