Typical Testing Data/Standard Curve (for reference only)
Human Corticoliberin ELISA Kit | CRH elisa kit
Human Corticoliberin ELISA Kit
Typical Testing Data/Standard Curve (for reference only)
Typical Testing Data/Standard Curve (for reference only)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the corticotropin-releasing factor family. The encoded preproprotein is proteolytically processed to generate the mature neuropeptide hormone. In response to stress, this hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus, binds to corticotropin releasing hormone receptors and stimulates the release of adrenocorticotropic hormone from the pituitary gland. Marked reduction in this protein has been observed in association with Alzheimer's disease. Autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes, and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturition. [provided by RefSeq, Nov 2015]
Uniprot Description
CRH: This hormone from hypothalamus regulates the release of corticotropin from pituitary gland. Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 8q13
Cellular Component: cytoplasm; extracellular region; extracellular space; perikaryon
Molecular Function: corticotropin-releasing hormone receptor 1 binding; corticotropin-releasing hormone receptor 2 binding; hormone activity; neuropeptide hormone activity; protein binding; receptor binding
Biological Process: adrenal gland development; associative learning; diterpenoid metabolic process; female pregnancy; glucocorticoid biosynthetic process; hypothalamus development; induction of apoptosis by hormones; inflammatory response; ion homeostasis; learning and/or memory; lung development; negative regulation of blood pressure; negative regulation of circadian sleep/wake cycle, REM sleep; negative regulation of epinephrine secretion; negative regulation of luteinizing hormone secretion; parturition; positive regulation of adrenocorticotropic hormone secretion; positive regulation of cAMP biosynthetic process; positive regulation of cell proliferation; positive regulation of cortisol secretion; positive regulation of protein amino acid phosphorylation; regulation of serotonin secretion; response to corticosterone stimulus; response to drug; response to estrogen stimulus; response to ethanol; response to ether; response to pain; signal transduction; synaptic transmission; synaptic transmission, dopaminergic
Disease: Acth Deficiency, Isolated
Research Articles on CRH
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Product Notes
The Human CRH crh (Catalog #AAA2884707) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2884707 ELISA Kit recognizes Human CRH. It is sometimes possible for the material contained within the vial of "Corticoliberin, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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