Cleavage and polyadenylation specificity factor subunit 3 (CPSF3) Recombinant Protein | CPSF3 recombinant protein
Recombinant Human Cleavage and polyadenylation specificity factor subunit 3 (CPSF3)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the metallo-beta-lactamase family. The encoded protein is a 73kDa subunit of the cleavage and polyadenylation specificity factor and functions as an endonuclease that recognizes the pre-mRNA 3'-cleavage site AAUAAA prior to polyadenylation. It also cleaves after the pre-mRNA sequence ACCCA during histone 3'-end pre-mRNA processing. [provided by RefSeq, Oct 2012]
Uniprot Description
Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity, and functions as mRNA 3'-end-processing endonuclease. Also involved in the histone 3'-end pre-mRNA processing. U7 snRNP-dependent protein that induces both the 3'-endoribonucleolytic cleavage of histone pre-mRNAs and acts as a 5' to 3' exonuclease for degrading the subsequent downstream cleavage product (DCP) of mature histone mRNAs. Cleavage occurs after the 5'-ACCCA-3' sequence in the histone pre-mRNA leaving a 3'hydroxyl group on the upstream fragment containing the stem loop (SL) and 5' phosphate on the downstream cleavage product (DCP) starting with CU nucleotides. The U7-dependent 5' to 3' exonuclease activity is processive and degrades the DCP RNA substrate even after complete removal of the U7-binding site. Binds to the downstream cleavage product (DCP) of histone pre-mRNAs and the cleaved DCP RNA substrate in a U7 snRNP dependent manner.
Research Articles on CPSF3
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Product Notes
The CPSF3 cpsf3 (Catalog #AAA1349531) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 2-684aa; Full Length of Mature Protein. The amino acid sequence is listed below: SAIPAEESDQ LLIRPLGAGQ EVGRSCIILE FKGRKIMLDC GIHPGLEGMD ALPYIDLIDP AEIDLLLISH FHLDHCGALP WFLQKTSFKG RTFMTHATKA IYRWLLSDYV KVSNISADDM LYTETDLEES MDKIETINFH EVKEVAGIKF WCYHAGHVLG AAMFMIEIAG VKLLYTGDFS RQEDRHLMAA EIPNIKPDIL IIESTYGTHI HEKREEREAR FCNTVHDIVN RGGRGLIPVF ALGRAQELLL ILDEYWQNHP ELHDIPIYYA SSLAKKCMAV YQTYVNAMND KIRKQININN PFVFKHISNL KSMDHFDDIG PSVVMASPGM MQSGLSRELF ESWCTDKRNG VIIAGYCVEG TLAKHIMSEP EEITTMSGQK LPLKMSVDYI SFSAHTDYQQ TSEFIRALKP PHVILVHGEQ NEMARLKAAL IREYEDNDEV HIEVHNPRNT EAVTLNFRGE KLAKVMGFLA DKKPEQGQRV SGILVKRNFN YHILSPCDLS NYTDLAMSTV KQTQAIPYTG PFNLLCYQLQ KLTGDVEELE IQEKPALKVF KNITVIQEPG MVVLEWLANP SNDMYADTVT TVILEVQSNP KIRKGAVQKV SKKLEMHVYS KRLEIMLQDI FGEDCVSVKD DSILSVTVDG KTANLNLETR TVECEEGSED DESLREMVEL AAQRLYEALT PVH . It is sometimes possible for the material contained within the vial of "Cleavage and polyadenylation specificity factor subunit 3 (CPSF3), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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