Cytoplasmic polyadenylation element-binding protein 4 (CPEB4) Recombinant Protein | CPEB4 recombinant protein

Recombinant Human Cytoplasmic polyadenylation element-binding protein 4 (CPEB4)

Cat. Num. AAA1374820

• Gene Names: CPEB4; CPE-BP4; hCPEB-4
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Cytoplasmic polyadenylation element-binding protein 4 (CPEB4); Recombinant Human Cytoplasmic polyadenylation element-binding protein 4 (CPEB4); CPEB4 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-729, Full length protein
• Sequence: MGDYGFGVLVQSNTGNKSAFPVRFHPHLQPPHHHQNATPSPAAFINNNTAANGSSAGSAWLFPAPATHNIQDEILGSEKAKSQQQEQQDPLEKQQLSPSPGQEAGILPETEKAKSEENQGDNSSENGNGKEKIRIESPVLTGFDYQEATGLGTSTQPLTSSASSLTGFSNWSAAIAPSSSTIINEDASFFHQGGVPAASANNGALLFQNFPHHVSPGFGGSFSPQIGPLSQHHPHHPHFQHHHSQHQQQRRSPASPHPPPFTHRNAAFNQLPHLANNLNKPPSPWSSYQSPSPTPSSSWSPGGGGYGGWGGSQGRDHRRGLNGGITPLNSISPLKKNFASNHIQLQKYARPSSAFAPKSWMEDSLNRADNIFPFPDRPRTFDMHSLESSLIDIMRAENDTIKGRLNYSYPGSDSSLLINARTYGRRRGQSSLFPMEDGFLDDGRGDQPLHSGLGSPHCFSHQNGERVERYSRKVFVGGLPPDIDEDEITASFRRFGPLIVDWPHKAESKSYFPPKGYAFLLFQDESSVQALIDACIEEDGKLYLCVSSPTIKDKPVQIRPWNLSDSDFVMDGSQPLDPRKTIFVGGVPRPLRAVELAMIMDRLYGGVCYAGIDTDPELKYPKGAGRVAFSNQQSYIAAISARFVQLQHGEIDKRVEVKPYVLDDQLCDECQGARCGGKFAPFFCANVTCLQYYCEYCWAAIHSRAGREFHKPLVKEGGDRPRHISFRWN
• Sequence Length: 729

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 815891022
• NCBI GeneID: 80315
• NCBI Accession #: NP_001295118.1
• NCBI GenBank Nucleotide #: NM_001308189.1
• UniProt Accession #: Q17RY0; Q7Z310; Q8N405; Q9C0J0; B7ZLQ7
• Molecular Weight: 36,212 Da
• NCBI Official Full Name: cytoplasmic polyadenylation element-binding protein 4 isoform b
• NCBI Official Synonym Full Names: cytoplasmic polyadenylation element binding protein 4
• NCBI Official Symbol: CPEB4
• NCBI Official Synonym Symbols: CPE-BP4; hCPEB-4
• NCBI Protein Information: cytoplasmic polyadenylation element-binding protein 4
• UniProt Protein Name: Cytoplasmic polyadenylation element-binding protein 4
• Protein Family: Cytoplasmic polyadenylation element-binding protein
• UniProt Gene Name: CPEB4
• UniProt Synonym Gene Names: KIAA1673; CPE-BP4; CPE-binding protein 4; hCPEB-4

Uniprot Description

Sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR (PubMed:24990967). RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism (PubMed:24990967). Regulates activation of unfolded protein response (UPR) in the process of adaptation to ER stress in liver, by maintaining translation of CPE-regulated mRNAs in conditions in which global protein synthesis is inhibited (). Required for cell cycle progression, specifically for cytokinesis and chromosomal segregation (PubMed:26398195). Plays a role as an oncogene promoting tumor growth and progression by positively regulating translation of t-plasminogen activator/PLAT (PubMed:22138752). Stimulates proliferation of melanocytes (PubMed:27857118). In contrast to CPEB1 and CPEB3, does not play role in synaptic plasticity, learning and memory ().