Mast cell carboxypeptidase A Recombinant Protein | CPA3 recombinant protein

Recombinant Human Mast cell carboxypeptidase A

Cat. Num. AAA717554

• Gene Names: CPA3; MC-CPA
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Mast cell carboxypeptidase A; Recombinant Human Mast cell carboxypeptidase A; Carboxypeptidase A3; CPA3 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 110-417aa; Full Length
• Sequence: IPGRHSYAKYNNWEKIVAWTEKMMDKYPEMVSRIKIGSTVEDNPLYVLKIGEKNERRKAIFTDCGIHAREWVSPAFCQWFVYQATKTYGRNKIMTKLLDRMNFYILPVFNVDGYIWSWTKNRMWRKNRSKNQNSKCIGTDLNRNFNASWNSIPNTNDPCADNYRGSAPESEKETKAVTNFIRSHLNEIKVYITFHSYSQMLLFPYGYTSKLPPNHEDLAKVAKIGTDVLSTRYETRYIYGPIESTIYPISGSSLDWAYDLGIKHTFAFELRDKGKFGFLLPESRIKPTCRETMLAVKFIAKYILKHTS
• Sequence Length: 417

• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

SDS-PAGE

Product Categories/Family for CPA3 recombinant protein

Cell Biology

References

Cloning of cDNAs that encode human mast cell carboxypeptidase A, and comparison of the protein with mouse mast cell carboxypeptidase A and rat pancreatic carboxypeptidases.Reynolds D.S., Gurley D.S., Stevens R.L., Sugarbaker D.J., Austen K.F., Serafin W.E.Proc. Natl. Acad. Sci. U.S.A. 86:9480-9484(1989) Cloning and characterization of the novel gene for mast cell carboxypeptidase A.Reynolds D.S., Gurley D.S., Austen K.F.J. Clin. Invest. 89:273-282(1992) The DNA sequence, annotation and analysis of human chromosome 3.Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.Nature 440:1194-1198(2006) Human skin mast cell carboxypeptidase functional characterization, cDNA cloning, and genealogy.Natsuaki M., Stewart C.B., Vanderslice P., Schwartz L.B., Natsuaki M., Wintroub B.U., Rutter W.J., Goldstein S.M.J. Invest. Dermatol. 99:138-145(1992) Human mast cell carboxypeptidase. Purification and characterization.Goldstein S.M., Kaempfer C.E., Kealey J.T., Wintroub B.U.J. Clin. Invest. 83:1630-1636(1989)

NCBI and Uniprot Product Information

• NCBI GI #: 221316749
• NCBI GeneID: 1359
• NCBI Accession #: NP_001861.2
• NCBI GenBank Nucleotide #: NM_001870.3
• UniProt Accession #: P15088; Q96E94
• Molecular Weight: 38 kDa
• NCBI Official Full Name: mast cell carboxypeptidase A preproprotein
• NCBI Official Synonym Full Names: carboxypeptidase A3
• NCBI Official Symbol: CPA3
• NCBI Official Synonym Symbols: MC-CPA
• NCBI Protein Information: mast cell carboxypeptidase A
• UniProt Protein Name: Mast cell carboxypeptidase A
• Protein Family: Mast cell carboxypeptidase
• UniProt Gene Name: CPA3
• UniProt Synonym Gene Names: MC-CPA
• UniProt Entry Name: CBPA3_HUMAN

NCBI Description

This gene encodes a member of the carboxypeptidase A family of zinc metalloproteases. The encoded preproprotein is proteolytically processed to generate a mature protease that is released by mast cells and may be involved in the degradation of endogenous proteins and the inactivation of venom-associated peptides. Expression of this gene may be elevated in human asthma patients. [provided by RefSeq, Nov 2015]

Uniprot Description

CPA3: Three different forms of human pancreatic procarboxypeptidase A have been isolated. This gene encodes a form which is obtained as a binary complex of a procarboxypeptidase A with proproteinase E and functions as a secretory granule metalloexopeptidase. [provided by RefSeq, Jan 2009]

Protein type: EC 3.4.17.1; Protease

Chromosomal Location of Human Ortholog: 3q24

Cellular Component: extracellular region; extracellular space; secretory granule; transport vesicle

Molecular Function: metallocarboxypeptidase activity; zinc ion binding

Biological Process: angiotensin maturation; cellular protein metabolic process; positive regulation of defense response to virus by host; proteolysis