Cytochrome c oxidase protein 20 homolog (COX20) Recombinant Protein | COX20 recombinant protein

Recombinant Human Cytochrome c oxidase protein 20 homolog (COX20), partial

• Gene Names: COX20; FAM36A
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Cytochrome c oxidase protein 20 homolog (COX20); Recombinant Human Cytochrome c oxidase protein 20 homolog (COX20); partial; COX20 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 130

• Species: Homo sapiens (Human)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 918410273
• NCBI GeneID: 116228
• NCBI Accession #: NP_001299800.1
• NCBI GenBank Nucleotide #: NM_001312871.1
• UniProt Accession #: Q5RI15; Q8WV86
• Molecular Weight: 14,669 Da
• NCBI Official Full Name: cytochrome c oxidase protein 20 homolog isoform 1
• NCBI Official Synonym Full Names: COX20, cytochrome c oxidase assembly factor
• NCBI Official Symbol: COX20
• NCBI Official Synonym Symbols: FAM36A
• NCBI Protein Information: cytochrome c oxidase assembly protein COX20, mitochondrial
• UniProt Protein Name: Cytochrome c oxidase assembly protein COX20, mitochondrial
• Protein Family: Cytochrome c oxidase protein
• UniProt Gene Name: COX20
• UniProt Synonym Gene Names: FAM36A

NCBI Description

This gene encodes a protein that plays a role in the assembly of cytochrome C oxidase, an important component of the respiratory pathway. It contains two transmembrane helices and localizes to the mitochondrial membrane. Mutations in this gene can cause mitochondrial complex IV deficiency, which results in ataxia and muscle hypotonia. There are multiple pseudogenes for this gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]

Uniprot Description

Essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase (PubMed:23125284). Acts as a chaperone in the early steps of cytochrome c oxidase subunit II (MT-CO2/COX2) maturation, stabilizing the newly synthesized protein and presenting it to metallochaperones SCO1/2 which in turn facilitates the incorporation of the mature MT-CO2/COX2 into the assembling CIV holoenzyme (PubMed:24403053).