MARK2 / PAR-1 Blocking Peptide | MARK2 blocking peptide
MARK2 / PAR-1 Immunizing Peptide
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the Par-1 family of serine/threonine protein kinases. The protein is an important regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins. The protein localizes to cell membranes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]
Uniprot Description
MARK2: a CAMK protein kinase of the CAMKL group. Plays a role in epithelial morphogenesis. Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. One or more isoforms may play a role in graft rejection. 12 isoforms of the human protein are produced by alternative promoter.
Protein type: Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Kinase, protein; EC 2.7.11.26; CAMK group; CAMKL family; MARK subfamily
Chromosomal Location of Human Ortholog: 11q13.1
Cellular Component: actin filament; lateral plasma membrane; membrane; mitochondrion; plasma membrane
Molecular Function: ATP binding; lipid binding; magnesium ion binding; protein binding; protein kinase activator activity; protein serine/threonine kinase activity; tau-protein kinase activity
Biological Process: activation of protein kinase activity; establishment and/or maintenance of epithelial cell polarity; establishment of cell polarity; mitochondrion degradation; mitochondrion localization; neuron migration; peptidyl-threonine phosphorylation; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of axonogenesis; regulation of cytoskeleton organization and biogenesis; Wnt receptor signaling pathway
Research Articles on MARK2
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Product Notes
The MARK2 mark2 (Catalog #AAA426521) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. The MARK2 / PAR-1 Immunizing Peptide reacts with Human, Mouse, Rat, Cow and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: C-QNGKDSTA PQR. It is sometimes possible for the material contained within the vial of "MARK2 / PAR-1, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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