DAB2/DOC2 Blocking Peptide | DAB2 blocking peptide

DAB2/DOC2 Immunizing Peptide

Cat. Num. AAA427633

• Gene Names: DAB2; DOC2; DOC-2
• Reactivity: Human, Rat, Dog, Cow
• Synonyms: DAB2/DOC2; DAB2/DOC2 Immunizing Peptide; DAB2; disabled homolog 2; mitogen-responsive phosphoprotein (Drosophila); DOC-2; DOC2; FLJ26626; differentially-expressed protein 2; mitogen-responsive phosphoprotein; Goat Anti-DAB2 / DOC2; mitogen-responsive; DAB2 blocking peptide

• Reactivity: Human, Rat, Dog, Cow
• Form/Format: 100ug of dried peptide
• Sequence: C-QQFDQISNRTGKQE
• Sequence Length: 770

• Corresponding Antibody: Catalog #MBS422558
• Preparation and Storage: Shipped at ambient temperature, store at -20 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 148491082
• NCBI GeneID: 1601
• NCBI Accession #: NP_001334.2
• NCBI GenBank Nucleotide #: NM_001343.3
• Molecular Weight: 80,228 Da
• NCBI Official Full Name: disabled homolog 2 isoform 1
• NCBI Official Synonym Full Names: Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
• NCBI Official Symbol: DAB2
• NCBI Official Synonym Symbols: DOC2; DOC-2
• NCBI Protein Information: disabled homolog 2; differentially-expressed protein 2; disabled homolog 2, mitogen-responsive phosphoprotein
• UniProt Protein Name: Disabled homolog 2
• Protein Family: Disabled
• UniProt Gene Name: DAB2
• UniProt Synonym Gene Names: DOC2
• UniProt Entry Name: DAB2_HUMAN

NCBI Description

This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Uniprot Description

DAB2: an adaptor protein that interacts with Grb2, myosin VI, SMAD2/3, DIP1/2, Dvl-3, the integrin betasubunit, and c-Src. Negatively regulates canonical Wnt signaling by stabilizing the beta-catenin degradation complex. A component of the CSF-1 signal transduction pathway. Phosphorylated DAB2 inhibits adhesion and integrin signaling. Two alternatively spliced isoforms are described.

Protein type: Tumor suppressor; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 5p13.1

Cellular Component: focal adhesion; intracellular membrane-bound organelle; clathrin-coated vesicle; lysosomal membrane; apical plasma membrane; nucleolus; plasma membrane; clathrin coated vesicle membrane; coated pit; clathrin coat of coated pit

Molecular Function: protein C-terminus binding; integrin binding; protein binding; phosphatidylinositol-4,5-bisphosphate binding; SMAD binding

Biological Process: cellular morphogenesis during differentiation; pinocytosis; apoptosis; positive regulation of transcription, DNA-dependent; positive regulation of endocytosis; excretion; activation of JNK activity; clathrin cage assembly; protein transport; positive regulation of RNA elongation from RNA polymerase II promoter; negative regulation of protein binding; positive regulation of receptor recycling; integrin-mediated signaling pathway; receptor-mediated endocytosis; Wnt receptor signaling pathway; leading edge cell differentiation; in utero embryonic development; positive regulation of transforming growth factor beta receptor signaling pathway; cell proliferation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; myeloid cell differentiation; positive regulation of protein amino acid phosphorylation; negative regulation of transcription, DNA-dependent; positive regulation of cell migration; endoderm development; negative regulation of apoptosis