CREB3L2 / BBF2H7 Blocking Peptide | CREB3L2 blocking peptide

CREB3L2 / BBF2H7 Immunizing Peptide

Gene Names

CREB3L2; BBF2H7

Reactivity

Human, Mouse, Rat, Dog, Cow

Synonyms

CREB3L2 / BBF2H7; CREB3L2 / BBF2H7 Immunizing Peptide; CREB3L2; cAMP responsive element binding protein 3-like 2; BBF2H7; MGC131709; MGC71006; B-ZIB transcription factor; FUS/BBF2H7 protein; TCAG_1951439; basic transcription factor 2; CREB3L2 blocking peptide

Ordering
Cat. Num. AAA428466 When autocomplete results are available use up and down arrows to review and enter to select. Touch device users, explore by touch or with swipe gestures. For Research Use Only!

Reactivity

Human, Mouse, Rat, Dog, Cow

Form/Format

100ug of dried peptide

Sequence

C-HSLQEPYTASVVRS

Sequence Length

520

Preparation and Storage

Shipped at ambient temperature, store at -20 degree C

NCBI and Uniprot Product Information

NCBI GI #

56550067

NCBI GeneID

64764

NCBI Accession #

NP_919047.2

NCBI GenBank Nucleotide #

NM_194071.3

Molecular Weight

27,722 Da

NCBI Official Full Name

cyclic AMP-responsive element-binding protein 3-like protein 2 isoform 1

NCBI Official Synonym Full Names

cAMP responsive element binding protein 3-like 2

NCBI Official Symbol

CREB3L2

NCBI Official Synonym Symbols

BBF2H7

NCBI Protein Information

cyclic AMP-responsive element-binding protein 3-like protein 2

UniProt Protein Name

Cyclic AMP-responsive element-binding protein 3-like protein 2

Protein Family

Cyclic AMP-responsive element-binding protein 3-like protein

UniProt Gene Name

CREB3L2

UniProt Synonym Gene Names

BBF2H7; cAMP-responsive element-binding protein 3-like protein 2

UniProt Entry Name

CR3L2_HUMAN

NCBI Description

This gene encodes a member of the oasis bZIP transcription factor family. Members of this family can dimerize but form homodimers only. The encoded protein is a transcriptional activator. Translocations between this gene on chromosome 7 and the gene fused in sarcoma on chromosome 16 can be found in some tumors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Uniprot Description

CREB3L2: Transcriptional activator which is processed and activated during endoplasmic reticulum stress late phase. Binds to the cAMP response element (CRE) and activates transcription through CRE. Regulates the transcription of unfolded protein response target genes, preventing accumulation of unfolded proteins in damaged neurons. Also regulates the expression of SEC23A, accelerating protein trafficking from the ER to the Golgi thereby playing a key role in chondrocyte differentiation and formation of epiphyseal cartilage. A chromosomal aberration involving CREB3L2 is found in low grade fibromyxoid sarcoma (LGFMS). Translocation t(7;16)(q33;p11) with FUS. Belongs to the bZIP family. ATF subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Oncoprotein; Transcription factor; Membrane protein, integral

Chromosomal Location of Human Ortholog: 7q34

Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; nucleoplasm; nucleus

Biological Process: cartilage development; chondrocyte differentiation; ER to Golgi vesicle-mediated transport; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; transcription from RNA polymerase II promoter; unfolded protein response

Research Articles on CREB3L2

1. These data suggest that the secreted luminal BBF2H7 C-terminus is involved in Hedgehog ligand-dependent cancer cell proliferation through activation of Hedgehog signaling. BBF2H7 C-terminus may be a novel target for the development of anticancer drugs.

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Product Notes

The CREB3L2 creb3l2 (Catalog #AAA428466) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. The CREB3L2 / BBF2H7 Immunizing Peptide reacts with Human, Mouse, Rat, Dog, Cow and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: C-HSLQEPYT ASVVRS. It is sometimes possible for the material contained within the vial of "CREB3L2 / BBF2H7, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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