THRA blocking peptide
THRA Immunizing Peptide
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Uniprot Description
TR-alpha: nuclear hormone receptor and transcription factor. High affinity receptor for triiodothyronine. Interacts with SRC-3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Four splice variant isoforms have been described.
Protein type: DNA-binding; Nuclear receptor; Transcription factor
Chromosomal Location of Human Ortholog: 17q11.2
Cellular Component: cytosol; mitochondrion; nucleoplasm; nucleus
Molecular Function: chromatin DNA binding; protein binding; protein complex binding; protein domain specific binding; protein heterodimerization activity; protein homodimerization activity; RNA polymerase II transcription factor activity, enhancer binding; steroid hormone receptor activity; TATA-binding protein binding; thyroid hormone receptor activity; transcription factor activity; transcription factor binding; zinc ion binding
Biological Process: adrenal gland development; brain development; cartilage condensation; cytoplasmic sequestering of transcription factor; embryonic organ development; erythrocyte differentiation; female courtship behavior; gut development; hormone-mediated signaling; intracellular receptor-mediated signaling pathway; kidney development; learning and/or memory; liver development; negative regulation of transcription factor activity; negative regulation of transcription, DNA-dependent; negative regulation of transcriptional preinitiation complex assembly; ossification; positive regulation of female receptivity; positive regulation of transcription from RNA polymerase II promoter; regulation of heart contraction; regulation of lipid catabolic process; regulation of myeloid cell apoptosis; regulation of transcription from RNA polymerase II promoter; response to cold; response to drug; response to nutrient levels; steroid hormone mediated signaling; thyroid gland development; transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter
Disease: Hypothyroidism, Congenital, Nongoitrous, 6
Research Articles on THRA
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Product Notes
The THRA thra (Catalog #AAA425705) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. The THRA Immunizing Peptide reacts with Human, Mouse, Rat, Dog, Pig, Cow and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: C-KEEMIRSL QQRP. It is sometimes possible for the material contained within the vial of "THRA, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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