SUV39H2 blocking peptide

SUV39H2 Immunizing Peptide

Cat. Num. AAA425529

• Gene Names: SUV39H2; KMT1B
• Reactivity: Human, Mouse, Rat, Dog, Pig, Cow
• Synonyms: SUV39H2; SUV39H2 Immunizing Peptide; suppressor of variation 3-9 (Drosophila) homolog 2 (Drosophila); FLJ23414; RP11-2K17.2; KMT1; uppressor of variegation 3-9 homolog 2 (Drosophila); KMT1B; suppressor of variegation 3-9 homolog 2; SUV39H2 blocking peptide

• Reactivity: Human, Mouse, Rat, Dog, Pig, Cow
• Form/Format: 100ug of dried peptide
• Sequence: CKCGAVTCRGYLN
• Sequence Length: 350

• Preparation and Storage: Shipped at ambient temperature, store at -20 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 13375930
• NCBI GeneID: 79723
• NCBI Accession #: NP_078946.1
• NCBI GenBank Nucleotide #: NM_024670.3
• Molecular Weight: 26,350 Da
• NCBI Official Full Name: histone-lysine N-methyltransferase SUV39H2 isoform 2
• NCBI Official Synonym Full Names: suppressor of variegation 3-9 homolog 2
• NCBI Official Symbol: SUV39H2
• NCBI Official Synonym Symbols: KMT1B
• NCBI Protein Information: histone-lysine N-methyltransferase SUV39H2
• UniProt Protein Name: Histone-lysine N-methyltransferase SUV39H2
• Protein Family: Histone-lysine N-methyltransferase
• UniProt Gene Name: SUV39H2
• UniProt Synonym Gene Names: KMT1B; H3-K9-HMTase 2; Su(var)3-9 homolog 2
• UniProt Entry Name: SUV92_HUMAN

Uniprot Description

SUV39H2: Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys- 9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Belongs to the histone-lysine methyltransferase family. Suvar3-9 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.1.1.43; Amino Acid Metabolism - lysine degradation; Methyltransferase, protein lysine; Methyltransferase

Chromosomal Location of Human Ortholog: 10p13

Cellular Component: chromatin; chromosome, pericentric region; nucleoplasm

Molecular Function: histone lysine N-methyltransferase activity (H3-K9 specific); histone-lysine N-methyltransferase activity; protein binding; zinc ion binding

Biological Process: cell cycle; cell differentiation; chromatin assembly or disassembly; chromatin remodeling; negative regulation of circadian rhythm; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; rhythmic process; transcription, DNA-dependent