Spleen tyrosine kinase / SYK Blocking Peptide | SYK blocking peptide
Spleen tyrosine kinase / SYK Immunizing Peptide
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
Uniprot Description
Syk: a cytoplasmic tyrosine kinase of the SYK family containing two SH2 domains. Plays a central role in the B cell receptor (BCR) response. An upstream activator of the PI3K, PLCgamma2, and Rac/cdc42 pathways in the BCR response. Required for the sequential events of Fc gamma IIa receptor-mediated phagocytosis. Expression highest in murine spleen, heart, mammary gland and thymus. Two splice variant isoforms have been described.
Protein type: Kinase, protein; Protein kinase, tyrosine (non-receptor); Protein kinase, TK; EC 2.7.10.2; TK group; Syk family
Chromosomal Location of Human Ortholog: 9q22
Cellular Component: B cell receptor complex; cytoplasm; cytosol; extrinsic to internal side of plasma membrane; nucleus; plasma membrane; protein complex; T cell receptor complex
Molecular Function: ATP binding; integrin binding; non-membrane spanning protein tyrosine kinase activity; protein binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; protein-tyrosine kinase activity; receptor signaling protein tyrosine kinase activity
Biological Process: activation of JNK activity; adaptive immune response; angiogenesis; B cell receptor signaling pathway; beta selection; blood vessel morphogenesis; cell proliferation; defense response to bacterium; inflammatory response; innate immune response; integrin-mediated signaling pathway; leukocyte activation during immune response; leukocyte adhesion; leukotriene biosynthetic process; lymph vessel development; macrophage activation during immune response; neutrophil activation during immune response; neutrophil chemotaxis; organ morphogenesis; peptidyl-serine phosphorylation; platelet activation; positive regulation of alpha-beta T cell differentiation; positive regulation of alpha-beta T cell proliferation; positive regulation of B cell differentiation; positive regulation of bone resorption; positive regulation of calcium-mediated signaling; positive regulation of cell adhesion mediated by integrin; positive regulation of cytokine secretion; positive regulation of gamma-delta T cell differentiation; positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process; positive regulation of interferon type I production; positive regulation of interleukin-3 biosynthetic process; positive regulation of mast cell degranulation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of receptor internalization; protein amino acid phosphorylation; receptor internalization; regulation of neutrophil degranulation; regulation of phagocytosis; regulation of superoxide release; regulation of transcription factor activity; serotonin secretion by platelet; stimulatory C-type lectin receptor signaling pathway; transcription factor import into nucleus; transmembrane receptor protein tyrosine kinase signaling pathway; viral reproduction
Research Articles on SYK
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Product Notes
The SYK syk (Catalog #AAA425490) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. The Spleen tyrosine kinase / SYK Immunizing Peptide reacts with Human, Mouse, Rat, Dog, Pig, Cow and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: C-KYLQQNRH VKDKN. It is sometimes possible for the material contained within the vial of "Spleen tyrosine kinase / SYK, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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