MTHFD1L blocking peptide
MTHFD1L Immunizing Peptide
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is involved in the synthesis of tetrahydrofolate (THF) in the mitochondrion. THF is important in the de novo synthesis of purines and thymidylate and in the regeneration of methionine from homocysteine. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2011]
Uniprot Description
MTHFD1L: May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic activities of MTHFD2. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Mitochondrial; Cofactor and Vitamin Metabolism - one carbon pool by folate; Carbohydrate Metabolism - glyoxylate and dicarboxylate; EC 6.3.4.3; Ligase
Chromosomal Location of Human Ortholog: 6q25.1
Cellular Component: cytosol; membrane; mitochondrial matrix; mitochondrion
Molecular Function: ATP binding; formate-tetrahydrofolate ligase activity; methenyltetrahydrofolate cyclohydrolase activity; methylenetetrahydrofolate dehydrogenase (NADP+) activity; protein homodimerization activity
Biological Process: embryonic neurocranium morphogenesis; embryonic viscerocranium morphogenesis; folic acid and derivative biosynthetic process; folic acid and derivative metabolic process; folic acid metabolic process; formate metabolic process; neural tube closure; one-carbon compound metabolic process; tetrahydrofolate metabolic process
Research Articles on MTHFD1L
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Product Notes
The MTHFD1L mthfd1l (Catalog #AAA427649) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. The MTHFD1L Immunizing Peptide reacts with Human, Mouse, Rat, Dog, Pig, Cow and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: C-DTNDRFLR KITIGQ. It is sometimes possible for the material contained within the vial of "MTHFD1L, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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