JAG1 blocking peptide
JAG1 Immunizing Peptide
NCBI and Uniprot Product Information
NCBI Description
The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis. [provided by RefSeq, Jul 2008]
Uniprot Description
JAG1: Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation. Enhances fibroblast growth factor-induced angiogenesis (in vitro). Interacts with NOTCH2 and NOTCH3. Interacts with NOTCH1 (in the presence of calcium ions). Widely expressed in adult and fetal tissues. In cervix epithelium expressed in undifferentiated subcolumnar reserve cells and squamous metaplasia. Expression is up-regulated in cervical squamous cell carcinoma. Expressed in bone marrow cell line HS-27a which supports the long-term maintenance of immature progenitor cells.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 20p12.1-p11.23
Cellular Component: adherens junction; apical plasma membrane; extracellular region; integral to plasma membrane; membrane; plasma membrane
Molecular Function: calcium ion binding; growth factor activity; Notch binding; protein binding; structural molecule activity
Biological Process: angiogenesis; auditory receptor cell differentiation; blood vessel remodeling; cell fate determination; endothelial cell differentiation; hemopoiesis; keratinocyte differentiation; morphogenesis of an epithelial sheet; myoblast differentiation; negative regulation of fat cell differentiation; negative regulation of neuron differentiation; nervous system development; Notch receptor processing; Notch signaling pathway; positive regulation of myeloid cell differentiation; positive regulation of Notch signaling pathway; positive regulation of osteoblast differentiation; positive regulation of transcription from RNA polymerase II promoter; regulation of cell migration; regulation of cell proliferation; response to muramyl dipeptide; T cell mediated immunity
Disease: Alagille Syndrome 1; Tetralogy Of Fallot
Research Articles on JAG1
Similar Products
Product Notes
The JAG1 jag1 (Catalog #AAA428230) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. The JAG1 Immunizing Peptide reacts with Human, Mouse, Rat, Dog, Pig, Cow and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: C-TNKQDNRD LESAQS. It is sometimes possible for the material contained within the vial of "JAG1, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
