GNAQ / ALPHA-q Blocking Peptide | GNAQ blocking peptide
GNAQ / ALPHA-q Immunizing Peptide
NCBI and Uniprot Product Information
NCBI Description
This locus encodes a guanine nucleotide-binding protein. The encoded protein, an alpha subunit in the Gq class, couples a seven-transmembrane domain receptor to activation of phospolipase C-beta. Mutations at this locus have been associated with problems in platelet activation and aggregation. A related pseudogene exists on chromosome 2.[provided by RefSeq, Nov 2010]
Uniprot Description
G-alpha(q): a guanine nucleotide-binding protein of the G12 class of G-alpha proteins. Agonist binding to Gq-coupled receptors may block Akt activation via the release of active G-alpha(q) subunits that inhibit phosphatidylinositol 3-kinase. Heterotrimeric G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.
Protein type: G protein; G protein, heterotrimeric alpha G(q); G protein, heterotrimeric
Chromosomal Location of Human Ortholog: 9q21
Cellular Component: cytoplasm; dendrite; lysosomal membrane; nuclear membrane; photoreceptor outer segment; plasma membrane
Molecular Function: G-protein beta/gamma-subunit binding; GTP binding; GTPase activator activity; GTPase activity; metal ion binding; protein binding; signal transducer activity; type 2A serotonin receptor binding
Biological Process: acetylcholine receptor signaling, muscarinic pathway; blood coagulation; dopamine receptor, phospholipase C activating pathway; embryonic digit morphogenesis; entrainment of circadian clock; forebrain neuron development; G-protein signaling, adenylate cyclase activating pathway; glutamate signaling pathway; heart development; maternal behavior; metabolic process; negative regulation of protein kinase activity; neuron remodeling; phospholipase C activation; phototransduction, visible light; pigmentation during development; platelet activation; positive regulation of GTPase activity; post-embryonic development; protein stabilization; regulation of action potential; regulation of melanocyte differentiation; skeletal development
Disease: Capillary Malformations, Congenital; Sturge-weber Syndrome
Research Articles on GNAQ
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Product Notes
The GNAQ gnaq (Catalog #AAA427680) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. The GNAQ / ALPHA-q Immunizing Peptide reacts with Human, Mouse, Rat, Dog, Pig, Cow and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: C-NDLDRVAD PAYLPT. It is sometimes possible for the material contained within the vial of "GNAQ / ALPHA-q, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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