DOCK1 blocking peptide
DOCK1 Immunizing Peptide
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the dedicator of cytokinesis protein family. Dedicator of cytokinesis proteins act as guanine nucleotide exchange factors for small Rho family G proteins. The encoded protein regulates the small GTPase Rac, thereby influencing several biological processes, including phagocytosis and cell migration. Overexpression of this gene has also been associated with certain cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Uniprot Description
DOCK1: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1. Interacts with the SH3 domains of CRK and NCK2 via multiple sites. Interacts with nucleotide-free RAC1 via its DHR-2 domain. Interacts with ELMO1, ELMO2 and probably ELMO3 via its SH3 domain. Interacts with RAC1 and BAI1. Highly expressed in placenta, lung, kidney, pancreas and ovary. Expressed at intermediate level in thymus, testes and colon. Belongs to the DOCK family.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis; Adaptor/scaffold; GEFs; GEFs, Rac/Rho
Chromosomal Location of Human Ortholog: 10q26.13-q26.3
Cellular Component: cytoplasm; cytosol; membrane; nucleoplasm; nucleus
Molecular Function: GTPase activator activity; guanyl-nucleotide exchange factor activity; protein binding; Rho guanyl-nucleotide exchange factor activity; SH3 domain binding
Biological Process: apoptosis; blood coagulation; cell migration; cytoskeleton organization and biogenesis; integrin-mediated signaling pathway; phagocytosis, engulfment; positive regulation of GTPase activity; signal transduction; small GTPase mediated signal transduction; vascular endothelial growth factor receptor signaling pathway
Research Articles on DOCK1
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Product Notes
The DOCK1 dock1 (Catalog #AAA425468) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. The DOCK1 Immunizing Peptide reacts with Human, Mouse, Rat, Dog, Pig, Cow and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: C-TTRKQTSV DSGIVQ. It is sometimes possible for the material contained within the vial of "DOCK1, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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