COVID 19 S Protein Spike RBD Coronavirus Recombinant Protein | COVID-19 recombinant protein
Recombinant 2019-nCoV S Protein RBD (C-6His) (Mammalian expression)
Applications
Immunogen, calibrator or standard.
Purity
>95% as determined by reducing SDS-PAGE. Affinity purification chromatography.
Synonyms
COVID 19 S Protein Spike RBD Coronavirus; Recombinant 2019-nCoV S Protein RBD (C-6His) (Mammalian expression); 2019 Novel Coronavirus; Coronavirus; CoV; COVID-19 virus; HCoV-2; Human Coronavirus 2019; SARS2; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; S Protein Spike RBD; Receptor Binding Domain; COVID-19 recombinant protein
Host
Human Cells
Purity/Purification
>95% as determined by reducing SDS-PAGE. Affinity purification chromatography.
Form/Format
Supplied as a 0.2um filtered solution of PBS, pH 7.4
Sequence Length
1273
Applicable Applications for COVID-19 recombinant protein
Immunogen, calibrator or standard.
Dry Ice Shipment
Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
Preparation and Storage
Reconstituted protein solution should be stored at <= -20 degree C.
Shipping: Ice packs
Shipping: Ice packs
Related Product Information for COVID-19 recombinant protein
Description: Recombinant 2019-nCoV S protein RBD Protein is produced by ourMammalian expression system and the target gene encoding Asn331-Val524 isexpressed with a 6His tag at the C-terminus.
Background: Protein S (PROS1) is glycoprotein and expressed in many cell typessupporting its reported involvement in multiple biological processes that includecoagulation, apoptosis, cancer development and progression, and the innate immuneresponse. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2, DPP4,CEACAM etc. The spike (S) glycoprotein of coronaviruses is known to be essential in thebinding of the virus to the host cell at the advent of the infection process. Most notable issevere acute respiratory syndrome (SARS). The severe acute respiratorysyndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate themembrane fusion required for virus entry and cell fusion. It is also a major immunogen anda target for entry inhibitors. It's been reported that 2019-nCoV can infect the humanrespiratory epithelial cells through interaction with the human ACE2 receptor. The spikeprotein is a large type I transmembrane protein containing two subunits, S1 and S2. S1mainly contains a receptor binding domain (RBD), which is responsible for recognizing thecell surface receptor. S2 contains basic elements needed for the membrane fusion.The Sprotein plays key parts in the induction of neutralizing-antibody and T-cell responses, aswell as protective immunity.
Background: Protein S (PROS1) is glycoprotein and expressed in many cell typessupporting its reported involvement in multiple biological processes that includecoagulation, apoptosis, cancer development and progression, and the innate immuneresponse. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2, DPP4,CEACAM etc. The spike (S) glycoprotein of coronaviruses is known to be essential in thebinding of the virus to the host cell at the advent of the infection process. Most notable issevere acute respiratory syndrome (SARS). The severe acute respiratorysyndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate themembrane fusion required for virus entry and cell fusion. It is also a major immunogen anda target for entry inhibitors. It's been reported that 2019-nCoV can infect the humanrespiratory epithelial cells through interaction with the human ACE2 receptor. The spikeprotein is a large type I transmembrane protein containing two subunits, S1 and S2. S1mainly contains a receptor binding domain (RBD), which is responsible for recognizing thecell surface receptor. S2 contains basic elements needed for the membrane fusion.The Sprotein plays key parts in the induction of neutralizing-antibody and T-cell responses, aswell as protective immunity.
NCBI and Uniprot Product Information
NCBI GI #
Molecular Weight
Molecular Weight: 22.6kDa
AP Molecular Weight: 28-35kDa, reducing conditions
AP Molecular Weight: 28-35kDa, reducing conditions
NCBI Official Full Name
surface glycoprotein
Similar Products
Product Notes
The COVID-19 (Catalog #AAA8574883) is a Recombinant Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's COVID 19 S Protein Spike RBD Coronavirus can be used in a range of immunoassay formats including, but not limited to, Immunogen, calibrator or standard. Researchers should empirically determine the suitability of the COVID-19 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "COVID 19 S Protein Spike RBD Coronavirus, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
