Rabbit anti-Human, Mouse PPM1D Polyclonal Antibody | anti-PPM1D antibody

PPM1D Polyclonal Antibody

Cat. Num. AAA2562074

• Gene Names: PPM1D; JDVS; WIP1; IDDGIP; PP2C-DELTA
• Reactivity: Human, Mouse
• Applications: Immunohistochemistry, ELISA
• Purity: Antigen Affinity Purification
• Synonyms: PPM1D; Polyclonal Antibody; PPM1D Polyclonal Antibody; EC 3.1.3.16; P53 induced protein phosphatase 1; P53-induced protein phosphatase 1; PP2C delta; PP2C-delta; PP2CD; Ppm1d; Protein phosphatase 1D; Protein phosphatase 1D magnesium-dependent delta isoform; Protein phosphatase 2C delta isoform; Protein phosphatase 2C isoform delta; Protein phosphatase magnesium dependent 1 delta; Protein phosphatase magnesium-dependent 1 delta; Protein phosphatase Mg2+/Mn2+ dependent 1D; Protein phosphatase Wip1; Wild type p53 induced phosphatase 1; WIP 1; WIP1; anti-PPM1D antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen Affinity Purification
• Form/Format: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
• Concentration: 0.5mg/mL (varies by lot)
• Sequence Length: 605

• Applicable Applications for anti-PPM1D antibody: Immunohistochemistry (IHC), ELISA (EIA)
• Application Notes: IHC: 1:50-1:300; ELISA: 1:2000-1:5000
• Immunogen: Fusion protein of human PPM1D
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human brain tissue using PPM1D Polyclonal Antibody at dilution of 1:60(×200))

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PPM1D Polyclonal Antibody at dilution of 1:60(×200))

Related Product Information for anti-PPM1D antibody

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. 

Product Categories/Family for anti-PPM1D antibody

Cancer; Signal Transduction

NCBI and Uniprot Product Information

• NCBI GI #: 4505997
• NCBI GeneID: 8493
• NCBI Accession #: NP_003611.1; BC033893
• NCBI GenBank Nucleotide #: NP_003611.1
• UniProt Accession #: O15297
• NCBI Official Full Name: protein phosphatase 1D
• NCBI Official Synonym Full Names: protein phosphatase, Mg2+/Mn2+ dependent 1D
• NCBI Official Symbol: PPM1D
• NCBI Official Synonym Symbols: JDVS; WIP1; IDDGIP; PP2C-DELTA
• NCBI Protein Information: protein phosphatase 1D
• UniProt Protein Name: Protein phosphatase 1D
• Protein Family: Protein phosphatase
• UniProt Gene Name: PPM1D
• UniProt Synonym Gene Names: WIP1; PP2C-delta
• UniProt Entry Name: PPM1D_HUMAN

NCBI Description

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. [provided by RefSeq, Jul 2008]