4-hydroxybenzoate polyprenyltransferase (Coq2) Recombinant Protein | Coq2 recombinant protein
Recombinant Mouse 4-hydroxybenzoate polyprenyltransferase, mitochondrial (Coq2)
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
NCBI and Uniprot Product Information
Uniprot Description
COQ2: Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB. Defects in COQ2 are the cause of coenzyme Q10 deficiency, primary, type 1 (COQ10D1). An autosomal recessive disorder with variable manifestations consistent with 5 major phenotypes. The phenotypes include an encephalomyopathic form with seizures and ataxia; a multisystem infantile form with encephalopathy, cardiomyopathy and renal failure; a predominantly cerebellar form with ataxia and cerebellar atrophy; Leigh syndrome with growth retardation; and an isolated myopathic form. Belongs to the UbiA prenyltransferase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Mitochondrial; Transferase; EC 2.5.1.39; Membrane protein, integral; Cofactor and Vitamin Metabolism - ubiquinone and other terpenoid-quinone biosynthesis
Cellular Component: integral to membrane; membrane; mitochondrial inner membrane; mitochondrion
Molecular Function: 4-hydroxybenzoate decaprenyltransferase activity; 4-hydroxybenzoate nonaprenyltransferase activity; prenyltransferase activity; transferase activity
Biological Process: glycerol metabolic process; isoprenoid biosynthetic process; ubiquinone biosynthetic process
Research Articles on Coq2
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Product Notes
The Coq2 coq2 (Catalog #AAA7012334) is a Recombinant Protein produced from Cell Free Expression and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 35-374aa; full length protein. This is a recombinant transmembrane protein expressed in a cell-free expression system. Researchers should empirically determine the suitability of the Coq2 coq2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: AGVPGARDRR APAPGTQRGR ALSLSAAAVV NSAPRPLQPY LRLMRLDKPI GTWLLYLPCT WSIGLAADPG CFPDWYMLSL FGTGAILMRG AGCTINDMWD RDFDKKVTRT ANRPIAAGDI STFQSFVFLG GQLTLALGVL LCLNYYSIAM GAASLLLVVT YPLVKRITFW PQLALGLTFN WGALLGWSAV KGSCDPAVCL PLYFSGVMWT LIYDTIYAHQ DKKDDALIGL KSTALLFQEN TRQWLSGFGV AMVAALSLAG ANNGQTVPYY AAVAAVGAHL AHQIYTVDIH RAEDCWDKFT SNRTVGMLLF LGIVLGNLCK EKTEEAKDAE AVRVGSEQTS. It is sometimes possible for the material contained within the vial of "4-hydroxybenzoate polyprenyltransferase (Coq2), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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