Chicken Collagen Type XVII ELISA Kit | COL17 elisa kit

Chicken Collagen Type XVII ELISA Kit

Cat. Num. AAA748230

• Gene Names: COL17A1; BP180; BPA-2; BPAG2; LAD-1; BA16H23.2
• Reactivity: Chicken
• Synonyms: Collagen Type XVII; Chicken Collagen Type XVII ELISA Kit; COL17 elisa kit

• Reactivity: Chicken

• Samples: Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
• Preparation and Storage: Store all reagents at 2-8 degree C.

Product Categories/Family for COL17 elisa kit

Epigenetics and Nuclear Signaling

NCBI and Uniprot Product Information

• NCBI GI #: 119569999
• NCBI GeneID: 1308
• Molecular Weight: 142,344 Da
• NCBI Official Full Name: collagen, type XVII, alpha 1, isoform CRA_b
• NCBI Official Synonym Full Names: collagen, type XVII, alpha 1
• NCBI Official Symbol: COL17A1
• NCBI Official Synonym Symbols: BP180; BPA-2; BPAG2; LAD-1; BA16H23.2
• NCBI Protein Information: collagen alpha-1(XVII) chain; collagen alpha-1(XVII) chain; alpha 1 type XVII collagen; type XVII collagen alpha-1; collagen XVII, alpha-1 polypeptide; 180 kDa bullous pemphigoid antigen 2; bullous pemphigoid antigen 2 (180kD); bA16H23.2 (collagen, type XVII, alpha 1 (BP180))
• UniProt Protein Name: Collagen alpha-1(XVII) chain
• UniProt Gene Name: COL17A1
• UniProt Synonym Gene Names: BP180; BPAG2; LAD-1; 97 kDa LAD antigen; 97-LAD; LABD97
• UniProt Entry Name: COHA1_HUMAN

NCBI Description

This gene encodes the alpha chain of type XVII collagen. Unlike most collagens, collagen XVII is a transmembrane protein. Collagen XVII is a structural component of hemidesmosomes, multiprotein complexes at the dermal-epidermal basement membrane zone that mediate adhesion of keratinocytes to the underlying membrane. Mutations in this gene are associated with both generalized atrophic benign and junctional epidermolysis bullosa. Two homotrimeric forms of type XVII collagen exist. The full length form is the transmembrane protein. A soluble form, referred to as either ectodomain or LAD-1, is generated by proteolytic processing of the full length form. [provided by RefSeq, Jul 2008]

Uniprot Description

COL17A1: May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane. Defects in COL17A1 are a cause of generalized atrophic benign epidermolysis bullosa (GABEB). GABEB is a non- lethal, adult form of junctional epidermolysis bullosa characterized by life-long blistering of the skin, associated with hair and tooth abnormalities. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Extracellular matrix

Chromosomal Location of Human Ortholog: 10q24.3

Cellular Component: collagen; hemidesmosome; integral to plasma membrane; endoplasmic reticulum lumen; plasma membrane; extracellular region; basement membrane; intercellular junction

Molecular Function: protein binding

Biological Process: extracellular matrix disassembly; collagen catabolic process; epidermis development; hemidesmosome assembly; extracellular matrix organization and biogenesis; cell-matrix adhesion

Disease: Epidermolysis Bullosa, Junctional, Non-herlitz Type