SDS-PAGE
Contactin 3 / CNTN3 Recombinant Protein | CNTN3 recombinant protein
Recombinant Human Contactin 3 / CNTN3 Protein (708 Asp/Asn, Fc tag)
Gene Names
CNTN3; PCS; PANG; BIG-1
Purity
> 90 % as determined by SDS-PAGE
Synonyms
Contactin 3 / CNTN3; Recombinant Human Contactin 3 / CNTN3 Protein (708 Asp/Asn; Fc tag); Contactin 3; CNTN3; PC; PANG; BIG-1; KIAA1496; CNTN3 recombinant protein
Host
Human Cells
Purity/Purification
> 90 % as determined by SDS-PAGE
Form/Format
Lyophilized from sterile 100mM Glycine, 10mM NaCl, 50mM Tris, pH 7.5
Sequence Length
1028
Application Notes
The recombinant human CNTN3/Fc chimera consists of 1221 amino acids and has a calculated molecular mass of 134.5 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rhCNTN3/Fc chimera is approximately 160-170 kDa due to glycosylation.
Predicted N Terminal
Glu 20
Endotoxin
< 1.0 EU per mug of the protein as determined by the LAL method
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -70 degree C
SDS-PAGE
SDS-PAGE
Related Product Information for CNTN3 recombinant protein
Background: Contactins are a subgroup of molecules belonging to the immunoglobulin superfamily that are expressed exclusively in the nervous system. The subgroup consists of six members: Contactin-1, Contactin-2 (TAG-1), Contactin-3 (BIG-1), BIG-2, Contactin-5 (NB-2) and NB-3. Since their identification in the late 1980s, Contactin-1 and Contactin-2 have been studied extensively. Axonal expression and the neurite extension activity of Contactin-1 and Contactin-2 attracted researchers to study the function of these molecules in axon guidance during development. Contactin-1 and Contactin-2 have come to be known as the principal molecules in the function and maintenance of myelinated neurons. In contrast, the function of the other four members of this subgroup remained unknown until recently. Contactin-3, also known as CNTN3 (BIG-1 in rat and PANG in mouse), is a GPI-linked glycoprotein that is expressed on cerebellar Purkinje cells, amygdaloid and thalamic neurons and olfactory granule cells. In the brain, Contactin-3 is expressed in frontal lobe, occipital lobe, cerebellum and amygdala. Contactin-3 contains 4 fibronectin type -III domains and 6 Ig-like C2-type (immunoglobulin-like) domains. Human Contactin-3 shares 92% aa identity with mouse Contactin-3.The exact function of Contactin-3 is unclear. Contactin-3 may mediate cell-cell interaction and may promote neurite outgrowth.
Description: A DNA sequence encoding the human CNTN3 precursor (NP_065923.1) (Met 1-Ser 1002, 708 Asp/Asn) was expressed with the fused Fc region of human IgG1 at the C-terminus.
Description: A DNA sequence encoding the human CNTN3 precursor (NP_065923.1) (Met 1-Ser 1002, 708 Asp/Asn) was expressed with the fused Fc region of human IgG1 at the C-terminus.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
112,883 Da
NCBI Official Full Name
contactin-3
NCBI Official Synonym Full Names
contactin 3
NCBI Official Symbol
CNTN3
NCBI Official Synonym Symbols
PCS; PANG; BIG-1
NCBI Protein Information
contactin-3
UniProt Protein Name
Contactin-3
Protein Family
UniProt Gene Name
CNTN3
UniProt Synonym Gene Names
KIAA1496; PANG; BIG-1
Uniprot Description
CNTN3: Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity. Belongs to the immunoglobulin superfamily. Contactin family.
Protein type: Cell adhesion; Cell surface; Membrane protein, GPI anchor
Chromosomal Location of Human Ortholog: 3p12.3
Research Articles on CNTN3
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Product Notes
The CNTN3 cntn3 (Catalog #AAA2546455) is a Recombinant Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase. The recombinant human CNTN3/Fc chimera consists of 1221 amino acids and has a calculated molecular mass of 134.5 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rhCNTN3/Fc chimera is approximately 160-170 kDa due to glycosylation. Researchers should empirically determine the suitability of the CNTN3 cntn3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Contactin 3 / CNTN3, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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