Mouse Contactin 1 ELISA Kit | CNTN1 elisa kit

Mouse Contactin 1 ELISA Kit

Cat. Num. AAA39702

• Gene Names: CNTN1; F3; GP135
• Reactivity: Mouse
• Synonyms: Contactin 1; Mouse Contactin 1 ELISA Kit; CNTN1 elisa kit

• Reactivity: Mouse
• Specificity: No significant cross-reactivity or interference between Mouse CNTN1 and analogues was observed.

• Samples: Serum, Plasma, Tissue Homogenate, Feces, Urine and Body Fluids
• Assay Type: Sandwich
• Detection Range: 31.2 pg/ml - 1000 pg/ml.
• Sensitivity: 5.0 pg/ml.
• Intended Uses: ELISA is a simple and highly sensitive method of analysis that allows for simultaneous and rapid quantification of a large number of samples. The assay is based on the specific recognition of the target compound (analyte/antigen) by antibodies which bind to the compound. The antigen-antibody complex is detected and measured with the aid of an enzyme-labeled antibody or antigen. Upon addition of a non-colored reagent, the enzyme produces a color reaction where the color intensity is directly or inversely proportional to the concentration of the analyte in the sample. This quantitative Sandwich ELISA kit is in tended to determinate CNTN1 concentrations in Mouse serum, plasma, tissue homogenates, feces, urine and body fluids, and it is only for research, not for drug, household, therapeutic applications
• Intra-assay Precision: Intra-assay CV (%) is less than 15%.
• Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean x100]
• Preparation and Storage: Store all reagents at 2-8 degree C

Typical Testing Data/Standard Curve (for reference only)

Related Product Information for CNTN1 elisa kit

Introduction: ELISA is a simple and highly sensitive method of analysis that allows for simultaneous and rapid quantification of a large number of samples. The assay is based on the specific recognition of the target compound (analyte/antigen) by antibodies which bind to the compound. The antigen-antibody complex is detected and measured with the aid of an enzyme-labeled antibody or antigen. Upon addition of a non-colored reagent, the enzyme produces a color reaction where the color intensity is directly or inversely proportional to the concentration of the analyte in the sample. This quantitative Sandwich ELISA kit is in tended to determinate CNTN1 concentrations in Mouse serum, plasma, tissue homogenates, feces, urine and body fluids, and it is only for research!

NCBI and Uniprot Product Information

• NCBI GI #: 366039951
• NCBI GeneID: 1272
• NCBI Accession #: NP_001242993.1
• NCBI GenBank Nucleotide #: NM_001256064.1
• UniProt Accession #: Q12860; Q12861; Q14030; Q7M4P0; Q8N466; A8K0H9; A8K0Y3
• Molecular Weight: 113,320 Da
• NCBI Official Full Name: contactin-1 isoform 3
• NCBI Official Synonym Full Names: contactin 1
• NCBI Official Symbol: CNTN1
• NCBI Official Synonym Symbols: F3; GP135
• NCBI Protein Information: contactin-1; glycoprotein gP135; neural cell surface protein F3
• UniProt Protein Name: Contactin-1
• Protein Family: Contactin
• UniProt Gene Name: CNTN1
• UniProt Entry Name: CNTN1_HUMAN

NCBI Description

The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Uniprot Description

CNTN1: Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth. Defects in CNTN1 are the cause of Compton-North congenital myopathy (CNCM). CNCM is a familial lethal form of congenital onset muscle weakness, inherited in an autosomal-recessive fashion and characterized by a secondary loss of beta2-syntrophin and alpha-dystrobrevin from the muscle sarcolemma, central nervous system involvement, and fetal akinesia. Belongs to the immunoglobulin superfamily. Contactin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, GPI anchor; Cell adhesion

Chromosomal Location of Human Ortholog: 12q11-q12

Cellular Component: membrane; plasma membrane

Molecular Function: carbohydrate binding; glycoprotein binding

Biological Process: axon guidance; Notch signaling pathway; cerebellum development; cell adhesion

Disease: Myopathy, Congenital, Compton-north