CCR4-NOT transcription complex subunit 6 (CNOT6) Recombinant Protein | CNOT6 recombinant protein

Recombinant Human CCR4-NOT transcription complex subunit 6 (CNOT6)

Cat. Num. AAA1478134

• Gene Names: CNOT6; CCR4; Ccr4a
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: CCR4-NOT transcription complex subunit 6 (CNOT6); Recombinant Human CCR4-NOT transcription complex subunit 6 (CNOT6); CNOT6 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-557, Full length protein
• Sequence: MPKEKYEPPDPRRMYTIMSSEEAANGKKSHWAELEISGKVRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPLTQDILNLYQEPDGTRRLLNYLLDNLSGTAKRITTEQPPPRSWIMLQEPDRTRPTALFSVMCYNVLCDKYATRQLYGYCPSWALNWDYRKKAIIQEILSCNADIVSLQEVETEQYYSFFLVELKERGYNGFFSPKSRARTMSEQERKHVDGCAIFFKTEKFTLVQKHTVEFNQLAMANSEGSEAMLNRVMTKDNIGVAVLLELRKESIEMPSGKPHLGTEKQLILVANAHMHWDPEYSDVKLVQTMMFLSEVKNIIDKASRNLKSSVLGEFGTIPLVLCADLNSLPDSGVVEYLSTGGVETNHKDFKELRYNESLTNFSCHGKNGTTNGRITHGFKLQSAYESGLMPYTNYTFDFKGIIDYIFYSKPQLNTLGILGPLDHHWLVENNISGCPHPLIPSDHFSLFAQLELLLPFLPQVNGIHLPGRR
• Sequence Length: 557

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for CNOT6 recombinant protein

This protein is a subunit of the CCR4-NOT core transcriptional regulation complex. The encoded protein has a 3 -5 RNase activity and prefers polyadenylated substates.

NCBI and Uniprot Product Information

• NCBI GI #: 735997432
• NCBI GeneID: 57472
• NCBI Accession #: NP_001290170.1
• NCBI GenBank Nucleotide #: NM_001303241.1
• UniProt Accession #: Q9ULM6; A7MD46; D3DWR0
• Molecular Weight: 63,307 Da
• NCBI Official Full Name: CCR4-NOT transcription complex subunit 6
• NCBI Official Synonym Full Names: CCR4-NOT transcription complex subunit 6
• NCBI Official Symbol: CNOT6
• NCBI Official Synonym Symbols: CCR4; Ccr4a
• NCBI Protein Information: CCR4-NOT transcription complex subunit 6
• UniProt Protein Name: CCR4-NOT transcription complex subunit 6
• Protein Family: CCR4-NOT transcription complex
• UniProt Gene Name: CNOT6
• UniProt Synonym Gene Names: CCR4; CCR4a; KIAA1194

NCBI Description

This gene encodes the catalytic component of the CCR4-NOT core transcriptional regulation complex. The encoded protein has a 3'-5' RNase activity and prefers polyadenylated substrates. The CCR4-NOT complex plays a role in many cellular processes, including miRNA-mediated repression, mRNA degradation, and transcriptional regulation. [provided by RefSeq, Dec 2014]

Uniprot Description

Poly(A) nuclease with 3'-5' RNase activity. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. In the presence of ZNF335, enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA. The increase of ligand-dependent ESR1-mediated transcription is much smaller, if any. Mediates cell proliferation and cell survival and prevents cellular senescence.