Chloride Intracellular Channel Protein 2 Recombinant Protein | CLIC2 recombinant protein

Recombinant Chloride Intracellular Channel Protein 2 (CLIC2)

Cat. Num. AAA2123428

• Gene Names: CLIC2; CLCNL2; CLIC2b; MRXS32; XAP121
• Applications: SDS-Page, Western Blot
• Purity: >95%
• Synonyms: Chloride Intracellular Channel Protein 2; Recombinant Chloride Intracellular Channel Protein 2 (CLIC2); CLIC2b; XAP121; CLIC2 recombinant protein

• Host: E Coli
• Purity/Purification: >95%
• Form/Format: Freeze-dried powder; PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Sequence Positions: Gln9~Ser247
• Sequence Length: 247

• Applicable Applications for CLIC2 recombinant protein: Positive Control, Immunogen, SDS-PAGE, Western Blot (WB)
• Source: Prokaryotic expression
• Species: Human
• Tag: N-terminal His Tag
• Subcellular Location: Secreted
• Isoelectric Point: 5.3
• Reconstitution: Reconstitute in PBS or others.
• Preparation and Storage: Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months. Avoid repeated freeze/thaw cycles.; Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Product Categories/Family for CLIC2 recombinant protein

Signal transduction

NCBI and Uniprot Product Information

• NCBI GI #: 66346733
• NCBI GeneID: 1193
• NCBI Accession #: NP_001280.3
• NCBI GenBank Nucleotide #: NP_001280.3
• UniProt Accession #: O15247
• Molecular Weight: Predicted Molecular Mass: 31.3kDa; Accurate Molecular Mass: 33kDa
• NCBI Official Full Name: chloride intracellular channel protein 2
• NCBI Official Synonym Full Names: chloride intracellular channel 2
• NCBI Official Symbol: CLIC2
• NCBI Official Synonym Symbols: CLCNL2; CLIC2b; MRXS32; XAP121
• NCBI Protein Information: chloride intracellular channel protein 2
• UniProt Protein Name: Chloride intracellular channel protein 2
• Protein Family: Chloride intracellular channel protein
• UniProt Gene Name: CLIC2
• UniProt Entry Name: CLIC2_HUMAN

NCBI Description

This gene encodes a chloride intracellular channel protein. Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. This protein plays a role in inhibiting the function of ryanodine receptor 2. A mutation in this gene is the cause of an X-linked form of cognitive disability. [provided by RefSeq, Jul 2017]

Uniprot Description

CLIC2: Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Modulates the activity of RYR2 and inhibits calcium influx. Belongs to the chloride channel CLIC family.

Protein type: Channel, chloride; Membrane protein, integral

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: cytoplasm; intracellular; nucleus

Molecular Function: chloride channel activity; protein binding; glutathione transferase activity; voltage-gated ion channel activity; glutathione peroxidase activity

Biological Process: transport; positive regulation of binding; signal transduction

Disease: Mental Retardation, X-linked, Syndromic 32