C-type lectin domain family 4 member M (CLEC4M) Recombinant Protein | CLEC4M recombinant protein

Recombinant Human C-type lectin domain family 4 member M (CLEC4M), partial

Cat. Num. AAA1408685

• Gene Names: CLEC4M; CD299; LSIGN; CD209L; L-SIGN; DCSIGNR; HP10347; DC-SIGN2; DC-SIGNR
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: C-type lectin domain family 4 member M (CLEC4M); Recombinant Human C-type lectin domain family 4 member M (CLEC4M); partial; CLEC4M recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 71-399
• Sequence: QVSKVPSSLS QEQSEQDAIY QNLTQLKAAV GELSEKSKLQ EIYQELTQLK AAVGELPEKS KLQEIYQELT RLKAAVGELP EKSKLQEIYQ ELTRLKAAVG ELPEKSKLQE IYQELTRLKA AVGELPEKSK LQEIYQELTE LKAAVGELPE KSKLQEIYQE LTQLKAAVGE LPDQSKQQQI YQELTDLKTA FERLCRHCPK DWTFFQGNCY FMSNSQRNWH DSVTACQEVR AQLVVIKTAE EQNFLQLQTS RSNRFSWMGL SDLNQEGTWQ WVDGSPLSPS FQRYWNSGEP NNSGNEDCAE FSGSGWNDNR CDVDNYWICK KPAACFRDE
• Sequence Length: 329

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 223278337
• NCBI GeneID: 10332
• NCBI Accession #: NP_001138377.1
• NCBI GenBank Nucleotide #: NM_001144905.1
• UniProt Accession #: Q9H2X3; Q69F40; Q969M4; Q96QP3; Q96QP4; Q96QP5; Q96QP6; Q9BXS3; Q9H2Q9; Q9H8F0; A6NKI4; A8K8B3
• Molecular Weight: 24,408 Da
• NCBI Official Full Name: C-type lectin domain family 4 member M isoform 12
• NCBI Official Synonym Full Names: C-type lectin domain family 4 member M
• NCBI Official Symbol: CLEC4M
• NCBI Official Synonym Symbols: CD299; LSIGN; CD209L; L-SIGN; DCSIGNR; HP10347; DC-SIGN2; DC-SIGNR
• NCBI Protein Information: C-type lectin domain family 4 member M
• UniProt Protein Name: C-type lectin domain family 4 member M
• Protein Family: C-type lectin domain family
• UniProt Gene Name: CLEC4M
• UniProt Synonym Gene Names: CD209L; CD209L1; CD299; DC-SIGNR; DC-SIGN2; L-SIGN

NCBI Description

This gene encodes a transmembrane receptor and is often referred to as L-SIGN because of its expression in the endothelial cells of the lymph nodes and liver. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses, with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are common and have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 30835; often referred to as DC-SIGN or CD209). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.[provided by RefSeq, Feb 2009]

Uniprot Description

Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates.