CLEC10A recombinant protein

Recombinant Human CLEC10A protein

Gene Names

CLEC10A; HML; MGL; HML2; CD301; CLECSF13; CLECSF14

Purity

>90% as determined by SDS-PAGE

Synonyms

CLEC10A; Recombinant Human CLEC10A protein; C-type lectin domain family 10 member A; C-type lectin superfamily member 14; Macrophage lectin 2; CD301; CLEC10A recombinant protein

Ordering
Cat. Num. AAA1561818 For Research Use Only!

Host

E Coli

Purity/Purification

>90% as determined by SDS-PAGE

Form/Format

Lyophilized. Lyophilized from PBS pH 7.4, 0.2% NLS, 5% Trehalose, 5% Mannose, 1mM EDTA.

Species

Homo sapiens (Human)

Protein Construction

A DNA sequence encoding the human CLEC10A (Thr71-Met239) was fused with His tag

Reconstitution

Reconstitute in sterile water for a stock solution.

Preparation and Storage

Store at 2 to 8 degree C for one week. Store at -20 to -80 degree C for twelve months from the date of receipt. Use a manual defrost freezer and avoid repeated freeze thaw cycles.
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Related Product Information for CLEC10A recombinant protein

Probable role in regulating adaptive and innate immune responses. Binds in a calcium-dependent manner to terminal galactose and N-acetylgalactosamine units, linked to serine or threonine. These sugar moieties are known as Tn-Ag and are expressed in a variety of carcinoma cells.

Product Categories/Family for CLEC10A recombinant protein

Protein

NCBI and Uniprot Product Information

NCBI GI #

59797948

NCBI GeneID

10462

UniProt Accession #

Q8IUN9; Q14538; Q6PIW3; A8K8J8

Molecular Weight

316

NCBI Official Full Name

C-type lectin domain family 10 member A

NCBI Official Synonym Full Names

C-type lectin domain family 10, member A

NCBI Official Symbol

CLEC10A

NCBI Official Synonym Symbols

HML; MGL; HML2; CD301; CLECSF13; CLECSF14

NCBI Protein Information

C-type lectin domain family 10 member A; macrophage lectin 2 (calcium dependent); C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 13 (macrophage-derived); C-type (calcium dependent, carbohydrate-recognition domain) l

UniProt Protein Name

C-type lectin domain family 10 member A

Protein Family

C-type lectin domain family

UniProt Gene Name

CLEC10A

UniProt Synonym Gene Names

CLECSF13; CLECSF14; HML

UniProt Entry Name

CLC10_HUMAN

NCBI Description

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may function as a cell surface antigen. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

CLEC10A: Probable role in regulating adaptive and innate immune responses. Binds in a calcium-dependent manner to terminal galactose and N-acetylgalactosamine units, linked to serine or threonine. These sugar moieties are known as Tn-Ag and are expressed in a variety of carcinoma cells. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: integral to membrane; plasma membrane

Molecular Function: carbohydrate binding

Biological Process: innate immune response; endocytosis

Research Articles on CLEC10A

1. expression of GalNAc moieties mirrors the T cell activation status, and thus only highly stimulated T cells are prone to the suppressive action of MGL.

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Product Notes

The CLEC10A clec10a (Catalog #AAA1561818) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "CLEC10A, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.