Claudin-11 Recombinant Protein | CLDN11 recombinant protein

Claudin-11 Protein, Human, Recombinant (mFc Tag)

Cat. Num. AAA8121238

• Gene Names: CLDN11; OSP; OTM
• Purity: >90% as determined by SDS-PAGE
• Synonyms: Claudin-11; Claudin-11 Protein; Human; Recombinant (mFc Tag); Human CLDN11/Claudin-11 Protein (Fc Tag); OSP Protein; OTM Protein; claudin 11; CLDN11 recombinant protein

• Host: HEK293 Cells
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Val23-Arg82

• Species: Human
• Endotoxin: <1.0EU per ug of the protein as determined by the LAL method
• Predicted N Terminal: Asp
• Tag: N-mouse IgG1-Fc
• Protein Construction: A DNA sequence encoding the human CLDN11 (O75508)(Val23-Arg82) was expressed with the Fc region of mouse IgG1 at the N-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Related Product Information for CLDN11 recombinant protein

Background: Claudin-11, also known as CLDN11, belongs to the group of claudins. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands function as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions.Claudin-11 is a tight junction associated protein and is a major component of central nervous system (CNS) myelin that is necessary for normal CNS function. Human blood-testis barrier disruption is related to a dysfunction of CLDN11 gene. It plays an important role in regulating proliferation and migration of oligodendrocytes.

References

Tsukita S, et al. (2001) Multifunctional strands in tight junctions. Nat Rev Mol Cell Biol. 2(4): 285-3.Heiskala M, et al. (2001) The roles of claudin superfamily proteins in paracellular transport. Traffic 2. (2):93-8.Bronstein JM, et al. (2000) Involvement of OSP/claudin-11 in oligodendrocyte membrane interactions: role in biology and disease. J Neurosci Res. 59(6):706-11.

NCBI and Uniprot Product Information

• NCBI GI #: 10938016
• NCBI GeneID: 5010
• NCBI Accession #: NP_005593.2
• NCBI GenBank Nucleotide #: NM_005602.5
• UniProt Accession #: O75508; Q5U0P3; B2R7C1; D3DNQ5
• Molecular Weight: 21,993 Da
• NCBI Official Full Name: claudin-11 isoform 1
• NCBI Official Synonym Full Names: claudin 11
• NCBI Official Symbol: CLDN11
• NCBI Official Synonym Symbols: OSP; OTM
• NCBI Protein Information: claudin-11; oligodendrocyte-specific protein; oligodendrocyte transmembrane protein
• UniProt Protein Name: Claudin-11
• Protein Family: Claudin
• UniProt Gene Name: CLDN11
• UniProt Synonym Gene Names: OSP; OTM
• UniProt Entry Name: CLD11_HUMAN

NCBI Description

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in the testis. This protein is a tight junction protein at the human blood-testis barrier (BTB), and the BTB disruption is related to a dysfunction of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Aug 2010]

Uniprot Description

Claudin-11: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. Belongs to the claudin family.

Protein type: Membrane protein, multi-pass; Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Ortholog: 3q26.2-q26.3

Cellular Component: tight junction; plasma membrane; integral to membrane

Molecular Function: identical protein binding; structural molecule activity

Biological Process: spermatogenesis; axon ensheathment; calcium-independent cell-cell adhesion