CLC4 Blocking Peptide | CLCN4 blocking peptide

CLC4 Antibody (C-term) Blocking Peptide

• Gene Names: CLCN4; CLC4; ClC-4; ClC-4A
• Synonyms: CLC4; CLC4 Antibody (C-term) Blocking Peptide; H(+)/Cl(-) exchange transporter 4; Chloride channel protein 4; ClC-4; Chloride transporter ClC-4; CLCN4; CLCN4 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the C-term region of human CLC4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
• Sequence Length: 760

• Cellular Location: Early endosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein
• Tissue Location: Abundant in skeletal muscle and also detectable in brain and heart
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for CLCN4 blocking peptide

Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons.

NCBI and Uniprot Product Information

• NCBI GI #: 20141247
• NCBI GeneID: 1183
• UniProt Accession #: P51793; Q9UBU1; A1L3U1; B7Z5Z4
• Molecular Weight: 74,347 Da
• NCBI Official Full Name: H(+)/Cl(-) exchange transporter 4
• NCBI Official Synonym Full Names: chloride voltage-gated channel 4
• NCBI Official Symbol: CLCN4
• NCBI Official Synonym Symbols: CLC4; ClC-4; ClC-4A
• NCBI Protein Information: H(+)/Cl(-) exchange transporter 4
• UniProt Protein Name: H(+)/Cl(-) exchange transporter 4
• Protein Family: H(+)/Cl(-) exchange transporter
• UniProt Gene Name: CLCN4
• UniProt Synonym Gene Names: ClC-4
• UniProt Entry Name: CLCN4_HUMAN

NCBI Description

The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 4 has an evolutionary conserved CpG island and is conserved in both mouse and hamster. This gene is mapped in close proximity to APXL (Apical protein Xenopus laevis-like) and OA1 (Ocular albinism type I), which are both located on the human X chromosome at band p22.3. The physiological role of chloride channel 4 remains unknown but may contribute to the pathogenesis of neuronal disorders. Alternate splicing results in two transcript variants that encode different proteins. [provided by RefSeq, Mar 2012]

Uniprot Description

CLCN4: Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons. Belongs to the chloride channel (TC 2.A.49) family. ClC-4/CLCN4 subfamily.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel

Chromosomal Location of Human Ortholog: Xp22.3

Cellular Component: endosome membrane

Molecular Function: antiporter activity; chloride channel activity

Biological Process: chloride transport; transport