Human Cardiotrophin Like Cytokine Factor 1 ELISA Kit | CLCF1 elisa kit

Human Cardiotrophin Like Cytokine Factor 1 ELISA Kit

Cat. Num. AAA22652

• Gene Names: CLCF1; CLC; NR6; BSF3; NNT1; BSF-3; CISS2; NNT-1
• Reactivity: Human
• Synonyms: Cardiotrophin Like Cytokine Factor 1; Human Cardiotrophin Like Cytokine Factor 1 ELISA Kit; CLCF1 elisa kit

• Reactivity: Human

• Assay Type: Sandwich
• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 7019351
• NCBI GeneID: 23529
• NCBI Accession #: NP_037378.1
• NCBI GenBank Nucleotide #: NM_013246.2
• UniProt Accession #: Q9UBD9; Q6NZA4; B4DNT4
• Molecular Weight: 25,176 Da
• NCBI Official Full Name: cardiotrophin-like cytokine factor 1 isoform 1
• NCBI Official Synonym Full Names: cardiotrophin-like cytokine factor 1
• NCBI Official Symbol: CLCF1
• NCBI Official Synonym Symbols: CLC; NR6; BSF3; NNT1; BSF-3; CISS2; NNT-1
• NCBI Protein Information: cardiotrophin-like cytokine factor 1; novel neurotrophin-1; B-cell stimulating factor 3; B-cell stimulatory factor 3; B-cell-stimulating factor 3; CRLF1 associated cytokine-like factor 1; neurotrophin-1/B-cell stimulating factor-3
• UniProt Protein Name: Cardiotrophin-like cytokine factor 1
• Protein Family: Cardiotrophin-like cytokine factor
• UniProt Gene Name: CLCF1
• UniProt Synonym Gene Names: BSF3; CLC; NNT1; BSF-3; NNT-1
• UniProt Entry Name: CLCF1_HUMAN

NCBI Description

This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009]

Uniprot Description

CLCF1: Cytokine with B-cell stimulating capability. Binds to and activates the ILST/gp130 receptor. Defects in CLCF1 are the cause of cold-induced sweating syndrome type 2 (CISS2). Cold-induced sweating syndrome (CISS) is an autosomal recessive disorder characterized by profuse sweating induced by cool surroundings (temperatures of 7 to 18 degrees Celsius). Additional abnormalities include a high- arched palate, nasal voice, depressed nasal bridge, inability to fully extend the elbows and kyphoscoliosis. Belongs to the IL-6 superfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide; Cytokine; Apoptosis

Chromosomal Location of Human Ortholog: 11q13.3

Cellular Component: extracellular region

Molecular Function: protein binding; growth factor activity; protein heterodimerization activity; cytokine activity; ciliary neurotrophic factor receptor binding; receptor binding

Biological Process: positive regulation of immunoglobulin production; cell surface receptor linked signal transduction; B cell differentiation; cytokine and chemokine mediated signaling pathway; positive regulation of cell proliferation; positive regulation of B cell proliferation; negative regulation of neuron apoptosis; JAK-STAT cascade; positive regulation of isotype switching to IgE isotypes; positive regulation of tyrosine phosphorylation of Stat3 protein; positive regulation of astrocyte differentiation

Disease: Cold-induced Sweating Syndrome 2