Citron Rho-interacting kinase (CIT) Recombinant Protein | CIT recombinant protein

Recombinant Human Citron Rho-interacting kinase (CIT) , partial

Cat. Num. AAA1147757

• Gene Names: CIT; CITK; CRIK; STK21; MCPH17
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Citron Rho-interacting kinase (CIT); Recombinant Human Citron Rho-interacting kinase (CIT); partial; CIT recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 2,069

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 332801082
• NCBI GeneID: 11113
• NCBI Accession #: NP_001193928.1
• NCBI GenBank Nucleotide #: NM_001206999.1
• UniProt Accession #: O14578; Q2M5E1; Q6XUH8; Q86UQ9; Q9UPZ7
• Molecular Weight: 236,607 Da
• NCBI Official Full Name: citron Rho-interacting kinase isoform 1
• NCBI Official Synonym Full Names: citron rho-interacting serine/threonine kinase
• NCBI Official Symbol: CIT
• NCBI Official Synonym Symbols: CITK; CRIK; STK21; MCPH17
• NCBI Protein Information: citron Rho-interacting kinase
• UniProt Protein Name: Citron Rho-interacting kinase
• Protein Family: Citron Rho-interacting kinase
• UniProt Gene Name: CIT
• UniProt Synonym Gene Names: CRIK; KIAA0949; STK21; CRIK

NCBI Description

This gene encodes a serine/threonine-protein kinase that functions in cell division. Together with the kinesin KIF14, this protein localizes to the central spindle and midbody, and functions to promote efficient cytokinesis. This protein is involved in central nervous system development. Polymorphisms in this gene are associated with bipolar disorder and risk for schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

Uniprot Description

Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2.