Neuronal acetylcholine receptor subunit beta-2 (CHRNB2) Recombinant Protein | CHRNB2 recombinant protein
Recombinant Human Neuronal acetylcholine receptor subunit beta-2 (CHRNB2)
NCBI and Uniprot Product Information
NCBI Description
Neuronal acetylcholine receptors are homo- or heteropentameric complexes composed of homologous alpha and beta subunits. They belong to a superfamily of ligand-gated ion channels which allow the flow of sodium and potassium across the plasma membrane in response to ligands such as acetylcholine and nicotine. This gene encodes one of several beta subunits. Mutations in this gene are associated with autosomal dominant nocturnal frontal lobe epilepsy. [provided by RefSeq, Jul 2008]
Uniprot Description
nAChRB2: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Defects in CHRNB2 are the cause of nocturnal frontal lobe epilepsy type 3 (ENFL3). ENFL3 is an autosomal dominant epilepsy characterized by nocturnal seizures with hyperkinetic automatisms and poorly organized stereotyped movements. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta- 2/CHRNB2 sub-subfamily.
Protein type: Membrane protein, integral; Receptor, misc.; Channel, cation; Channel, ligand-gated; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 1q21.3
Cellular Component: nicotinic acetylcholine-gated receptor-channel complex; postsynaptic membrane; plasma membrane; integral to membrane; cell junction; external side of plasma membrane
Molecular Function: protein heterodimerization activity; acetylcholine receptor activity; drug binding; acetylcholine binding; nicotinic acetylcholine-activated cation-selective channel activity; ligand-gated ion channel activity
Biological Process: response to nicotine; positive regulation of dopamine secretion; protein heterooligomerization; regulation of dendrite morphogenesis; behavioral response to nicotine; locomotory behavior; regulation of circadian sleep/wake cycle, non-REM sleep; sensory perception of pain; signal transduction; regulation of dopamine secretion; synaptic transmission, cholinergic; synaptic transmission; sensory perception of sound; regulation of synaptic transmission, dopaminergic; smooth muscle contraction; visual perception; conditioned taste aversion; calcium ion transport; positive regulation of B cell proliferation; visual learning; synaptic transmission involved in micturition; associative learning; regulation of circadian sleep/wake cycle, REM sleep; vestibulocochlear nerve development; regulation of action potential; B cell activation; regulation of dopamine metabolic process; positive regulation of synaptic transmission, dopaminergic; central nervous system projection neuron axonogenesis; optic nerve morphogenesis; learning; negative regulation of action potential; social behavior; response to cocaine; memory; neurological system process; membrane depolarization; response to ethanol; regulation of synaptogenesis; response to hypoxia; ion transport; cognition; lateral geniculate nucleus development
Disease: Epilepsy, Nocturnal Frontal Lobe, 3
Research Articles on CHRNB2
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Product Notes
The CHRNB2 chrnb2 (Catalog #AAA949533) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 26-502. The amino acid sequence is listed below: TDTEERLVEH LLDPSRYNKL IRPATNGSEL VTVQLMVSLA QLISVHEREQ IMTTNVWLTQ EWEDYRLTWK PEEFDNMKKV RLPSKHIWLP DVVLYNNADG MYEVSFYSNA VVSYDGSIFW LPPAIYKSAC KIEVKHFPFD QQNCTMKFRS WTYDRTEIDL VLKSEVASLD DFTPSGEWDI VALPGRRNEN PDDSTYVDIT YDFIIRRKPL FYTINLIIPC VLITSLAILV FYLPSDCGEK MTLCISVLLA LTVFLLLISK IVPPTSLDVP LVGKYLMFTM VLVTFSIVTS VCVLNVHHRS PTTHTMAPWV KVVFLEKLPA LLFMQQPRHH CARQRLRLRR RQREREGAGA LFFREAPGAD SCTCFVNRAS VQGLAGAFGA EPAPVAGPGR SGEPCGCGLR EAVDGVRFIA DHMRSEDDDQ SVSEDWKYVA MVIDRLFLWI FVFVCVFGTI GMFLQPLFQN YTTTTFLHSD HSAPSSK. It is sometimes possible for the material contained within the vial of "Neuronal acetylcholine receptor subunit beta-2 (CHRNB2), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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