Rat cholinergic receptor, nicotinic, alpha 7 ELISA Kit | CHRNA7 elisa kit
Rat Neuronal acetylcholine receptor subunit alpha-7, CHRNA7 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
subunit of nicotinic acetylcholline receptor; may mediate nicotine induced increase in tyrosine hydroxylase expression; may play a role in neuroprotection [RGD, Feb 2006]
Uniprot Description
nAChRA7: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha- 7/CHRNA7 sub-subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Channel, cation; Membrane protein, multi-pass; Channel, ligand-gated
Cellular Component: nicotinic acetylcholine-gated receptor-channel complex; dendrite; postsynaptic density; dendritic spine; lipid raft; presynaptic membrane; asymmetric synapse; postsynaptic membrane; growth cone; cell soma; membrane; axon; cytoplasm; apical plasma membrane; plasma membrane; dendritic shaft; cell junction; external side of plasma membrane
Molecular Function: toxin binding; protein binding; protein homodimerization activity; chloride channel regulator activity; beta-amyloid binding; acetylcholine-gated cation channel activity; acetylcholine receptor activity; drug binding; nicotinic acetylcholine-activated cation-selective channel activity; acetylcholine binding; protein kinase binding; ATPase binding; adenylate cyclase binding
Biological Process: response to nicotine; T cell activation; activation of MAPK activity; generation of action potential; behavioral response to nicotine; behavioral response to ethanol; dopamine biosynthetic process; signal transduction; positive regulation of heart rate in baroreceptor response to decreased systemic arterial blood pressure; synaptic transmission, cholinergic; regulation of synaptic transmission, dopaminergic; ovulation cycle; calcium ion transport; positive regulation of cell proliferation; negative regulation of interleukin-6 production; associative learning; response to food; B cell activation; endocytosis; negative regulation of tumor necrosis factor production; negative regulation of interleukin-1 beta production; regulation of norepinephrine secretion; memory; cellular calcium ion homeostasis; generation of ovulation cycle rhythm; sperm motility; positive regulation of angiogenesis; regulation of membrane potential; response to ethanol; negative regulation of inflammatory response; regulation of inflammatory response; response to hypoxia; ion transport; cognition
Research Articles on CHRNA7
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Product Notes
The Rat CHRNA7 chrna7 (Catalog #AAA9340394) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9340394 ELISA Kit recognizes Rat CHRNA7. It is sometimes possible for the material contained within the vial of "cholinergic receptor, nicotinic, alpha 7, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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