VAP-1 active protein
Human VAP-1
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the semicarbazide-sensitive amine oxidase family. Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes in the presence of copper and quinone cofactor. The encoded protein is localized to the cell surface, has adhesive properties as well as monoamine oxidase activity, and may be involved in leukocyte trafficking. Alterations in levels of the encoded protein may be associated with many diseases, including diabetes mellitus. A pseudogene of this gene has been described and is located approximately 9-kb downstream on the same chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]
Uniprot Description
Function: Cell adhesion protein that participates in lymphocyte recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion. Has a monoamine oxidase activity. May play a role in adipogenesis. Ref.2 Ref.9 Ref.10
Catalytic activity: RCH2NH2 + H2O + O2 = RCHO + NH3 + H2O2.
Cofactor: Binds 1 copper ion per subunit.Binds 2 calcium ions per subunit.Contains 1 topaquinone per subunit.
Subunit structure: Homodimer; disulfide-linked. Forms a heterodimer with AOC2. Ref.10 Ref.13
Subcellular location: Membrane; Single-pass type II membrane protein Ref.2.
Tissue specificity: Strongly expressed on the high endothelial venules of peripheral lymph nodes and on hepatic endothelia. Also highly expressed in appendix, lung and small intestine. Expressed also in adipose tissue, in bone marrow, colon, heart, kidney, ovary, pancreas, placenta, prostate, skeletal muscle, spleen and testis. Ref.2 Ref.9
Induction: Up-regulated during in vitro adipocyte differentiation. Ref.9
Post-translational modification: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.N- and O-glycosylated. Ref.12 Ref.13
Sequence similarities: Belongs to the copper/topaquinone oxidase family.
Biophysicochemical propertiesKinetic parameters:KM=1.94 mM for 2-phenylethylamine Ref.10KM=0.67 mM for methylamine
Research Articles on VAP-1
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Product Notes
The VAP-1 aoc3 (Catalog #AAA692022) is an Active Protein produced from CHO Cells and is intended for research purposes only. The product is available for immediate purchase. The Human VAP-1 reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: GRGGDGGEPS QLPHCPSVSP SAQPWTHPGQ SQLFADLSRE ELTAVM RFLT QRLGPGLVDA AQARPSDNCV FSVELQLPPK AAALAHLDRG S PPPAREALA IVFFGRQPQP NVSELVVGPL PHPSYMRDVT VERHGGP LPY HRRPVLFQEY LDIDQMIFNR ELPQASGLLH HCCFYKHRGR NL VTMTTAPR GLQSGDRATW FGLYYNISGA GFFLHHVGLE LLVNHKAL DP ARWTIQKVFY QGRYYDSLAQ LEAQFEAGLV NVVLIPDNGT GGS WSLKSPV PPGPAPPLQF YPQGPRFSVQ GSRVASSLWT FSFGLGAFS G PRIFDVRFQG ERLVYEISLQ EALAIYGGNS PAAMTTRYVD GGFG MGKYTT PLTRGVDCPY LATYVDWHFL LESQAPKTIR DAFCVFEQNQ GLPLRRHHSD LYSHYFGGLA ETVLVVRSMS TLLNYDYVWD TVFHP SGAIE IRFYATGYIS SAFLFGATGK YGNQVSEHTL GTVHTHSAHF KVDLDVAGLE NWVWAEDMVF VPMAVPWSPE HQLQRLQVTR KLLEME EQAA FLVGSATPRY LYLASNHSNK WGHPRGYRIQ MLSFAGEPLP Q NSSMARGFS WERYQLAVTQ RKEEEPSSSS VFNQNDPWAP TVDFSDF INN ETIAGKDLVA WVTAGFLHIP HAEDIPNTVT VGNGVGFFLR PY NFFDEDPS FYSADSIYFR GDQDAGACEV NPLACLPQAA ACAPDLPA FS HGGFSHN. It is sometimes possible for the material contained within the vial of "VAP-1, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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