GDF-2 active protein
Human GDF-2
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in rodents suggest that this protein plays a role in the adult liver and in differentiation of cholinergic central nervous system neurons. Mutations in this gene are associated with hereditary hemorrhagic telangiectasia. [provided by RefSeq, Jan 2014]
Uniprot Description
Function: Potent circulating inhibitor of angiogenesis. Could be involved in bone formation. Signals through the type I activin receptor ACVRL1 but not other Alks. Signaling through SMAD1 in endothelial cells requires TGF-beta coreceptor endoglin/ENG. Ref.6 Ref.8 Ref.10
Subunit structure: Homodimer; disulfide-linked. Interacts with ENG. Ref.7 Ref.8 Ref.9 Ref.11 Ref.12
Subcellular location: Secreted Ref.6.
Sequence similarities: Belongs to the TGF-beta family.
Research Articles on GDF-2
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Product Notes
The GDF-2 gdf2 (Catalog #AAA691750) is an Active Protein produced from CHO Cells and is intended for research purposes only. The product is available for immediate purchase. The Human GDF-2 reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: SAGAGSHCQK TSLRVNFEDI GWDSWIIAPK EYEAYECKGG CFFPLA DDVT PTKHAIVQTL VHLKFPTKVG KACCVPTKLS PISVLYKDDM G VPTLKYHYE GMSVAECGCR. It is sometimes possible for the material contained within the vial of "GDF-2, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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