FRP-4 active protein

Human FRP-4, soluble

Cat. Num. AAA692513

• Gene Names: SFRP4; PYL; FRP-4; FRPHE; FRZB-2; sFRP-4
• Reactivity: Human
• Purity: > 95% by SDS-PAGE & HPLC analyses
• Synonyms: FRP-4; Human FRP-4; soluble; Secreted frizzled-related protein 4; DDC-4 (rat homologue); FRP-4 active protein

• Host: CHO cells
• Reactivity: Human
• Purity/Purification: > 95% by SDS-PAGE & HPLC analyses
• Form/Format: Lyophilized
• Sequence: VRGAPCEAVR IPMCRHMPWN ITRMPNHLHH STQENAILAI EQYEEL VDVN CSAVLRFFLC AMYAPICTLE FLHDPIKPCK SVCQRARDDC E PLMKMYNHS WPESLACDEL PVYDRGVCIS PEAIVTDLPE DVKWIDI TPD MMVQERPLDV DCKRLSPDRC KCKKVKPTLA TYLSKNYSYV IH AKIKAVQR SGCNEVTTVV DVKEIFKSSS PIPRTQVPLI TNSSCQCP HI LPHQDVLIMC YEWRSRMMLL ENCLVEKWRD QLSKRSIQWE ERL QEQRRTV QDKKKTAGRT SRSNPPKPKG KPPAPKPASP KKNIKTRSA Q KRTNPKRV
• Sequence Length: 346

• Biological Activity: Determined by its ability to decrease alkaline phosphatase activity in CCL-226 cells when treated with 25ng/ml of Murine Wnt-3a.

Related Product Information for FRP-4 active protein

Secreted Frizzled-Related Proteins (sFRPs) are a family of glycosylated Wnt antagonists characterized by a conserved cysteine-rich domain that shares homology with the cysteine-rich, extracellular domain Frizzled proteins use for the binding of Wnt proteins and receptors. Lacking the transmembrane and intracellular domains of the Frizzled proteins, sFRPs function as soluble modulators of the Wnt signaling pathway through the direct binding of Wnt proteins to this cysteine-rich domain, and the resultant inhibition of Wnt receptor binding and signaling capabilities. sFRP-4 is widely distributed in a variety of embryonic and adult tissues where it can function as a circulating antiangiogenic factor, a potent proapoptotic factor, an inhibitor of insulin secretion, and a suppressor of both tumor growth and metastatic potential through disruption of the Wnt signaling pathway. Research has demonstrated the existence of a direct correlation between the downregulation and/or absence of circulating sFRP-4 and the progression of several cancer types, including ovarian, endometrial, prostate and lung. Upregulation of circulating sFRP-4 has been linked to the deterioration of glucose metabolism in the case of type 2 diabetes, as well as the suppression of the keratinocyte hyperproliferation and epidermal hyperlasia that are definitive of psoriasis. CHO cell-derived recombinant human sFRP-4 is a glycoprotein of 328 amino acid residues that contains a cysteine-rich, Frizzled-homologous domain. The calculated molecular weight of CHO cell-derived Recombinant Human sFRP-4 is 37.8 kDa; however, due to glycosylation, the protein migrates at an apparent molecular weight of approximately 55 - 65 kDa by SDS-PAGE analysis under reducing conditions.

Product Categories/Family for FRP-4 active protein

Soluble receptors

NCBI and Uniprot Product Information

• NCBI GI #: 170784838
• NCBI GeneID: 6424
• NCBI Accession #: NP_003005.2
• NCBI GenBank Nucleotide #: NM_003014.3
• UniProt Accession #: Q6FHJ7; O14877; Q05BG7; Q1ZYW2; Q4G124; Q6FHM0; Q6PD64; B4DYC1
• Molecular Weight: 39,827 Da
• NCBI Official Full Name: secreted frizzled-related protein 4
• NCBI Official Synonym Full Names: secreted frizzled related protein 4
• NCBI Official Symbol: SFRP4
• NCBI Official Synonym Symbols: PYL; FRP-4; FRPHE; FRZB-2; sFRP-4
• NCBI Protein Information: secreted frizzled-related protein 4
• UniProt Protein Name: Secreted frizzled-related protein 4
• UniProt Gene Name: SFRP4
• UniProt Synonym Gene Names: FRPHE; sFRP-4; FrpHE

NCBI Description

Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. The expression of SFRP4 in ventricular myocardium correlates with apoptosis related gene expression. [provided by RefSeq, Jul 2008]

Uniprot Description

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types (). SFRP4 plays a role in bone morphogenesis. May also act as a regulator of adult uterine morphology and function. May also increase apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (). Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake (PubMed:12952927).